Reprogramming of hepatic fat accumulation and 'browning' of adipose tissue by the short-chain fatty acid acetate

• Published in: International Journal of Obesity Vol. 40; no. 6; pp. 955 - 963
• Main Authors: Sahuri-Arisoylu, M, Brody, L P, Parkinson, J R, Parkes, H, Navaratnam, N, Miller, A D, Thomas, E L, Frost, G, Bell, J D
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 01.06.2016; Nature Publishing Group
• Subjects: 38/39; 59/57; 631/443/319/2723; 631/443/319/333/1465; 64/60; 82/80; Accumulation; Acetic acid; Acetic Acid - chemistry; Adipocytes, Brown - drug effects; Adipocytes, Brown - metabolism; Adipogenesis - drug effects; Adipose tissue; Adipose Tissue - drug effects; Adipose Tissue - metabolism; Adipose Tissue, White - drug effects; Adipose Tissue, White - metabolism; Adipose tissues; Analysis; Animals; Appetite; Body fat; Body weight; Browning; Carbohydrates; Diet; Disease Models, Animal; Epidemiology; Fatty acids; Fatty Acids - chemistry; Fatty Acids - pharmacology; Fermentation; Health aspects; Health Promotion and Disease Prevention; High fat diet; Internal Medicine; Kinases; Life sciences; Lipid Metabolism - drug effects; Lipids; Lipolysis; Liver; Liver - drug effects; Liver - metabolism; Male; Medical research; Medicine; Medicine & Public Health; Metabolic Diseases; Metabolism; Mice; Mice, Inbred C57BL; Microbiomes; Mitochondria; Mitochondrial DNA; Nanoparticles; original-article; Physiological aspects; Public Health; Reduction; Signal Transduction - drug effects; United Kingdom > UK; United States > US

Background/Objectives: Short-chain fatty acids, produced by microbiome fermentation of carbohydrates, have been linked to a reduction in appetite, body weight and adiposity. However, determining the contribution of central and peripheral mechanisms to these effects has not been possible. Subjects/Me...