Reprogramming of hepatic fat accumulation and 'browning' of adipose tissue by the short-chain fatty acid acetate

Background/Objectives: Short-chain fatty acids, produced by microbiome fermentation of carbohydrates, have been linked to a reduction in appetite, body weight and adiposity. However, determining the contribution of central and peripheral mechanisms to these effects has not been possible. Subjects/Me...

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Published inInternational Journal of Obesity Vol. 40; no. 6; pp. 955 - 963
Main Authors Sahuri-Arisoylu, M, Brody, L P, Parkinson, J R, Parkes, H, Navaratnam, N, Miller, A D, Thomas, E L, Frost, G, Bell, J D
Format Journal Article
LanguageEnglish
Published London Nature Publishing Group UK 01.06.2016
Nature Publishing Group
Subjects
38/39
59/57
631/443/319/2723
631/443/319/333/1465
64/60
82/80
Accumulation
Acetic acid
Acetic Acid - chemistry
Adipocytes, Brown - drug effects
Adipocytes, Brown - metabolism
Adipogenesis - drug effects
Adipose tissue
Adipose Tissue - drug effects
Adipose Tissue - metabolism
Adipose Tissue, White - drug effects
Adipose Tissue, White - metabolism
Adipose tissues
Analysis
Animals
Appetite
Body fat
Body weight
Browning
Carbohydrates
Diet
Disease Models, Animal
Epidemiology
Fatty acids
Fatty Acids - chemistry
Fatty Acids - pharmacology
Fermentation
Health aspects
Health Promotion and Disease Prevention
High fat diet
Internal Medicine
Kinases
Life sciences
Lipid Metabolism - drug effects
Lipids
Lipolysis
Liver
Liver - drug effects
Liver - metabolism
Male
Medical research
Medicine
Medicine & Public Health
Metabolic Diseases
Metabolism
Mice
Mice, Inbred C57BL
Microbiomes
Mitochondria
Mitochondrial DNA
Nanoparticles
original-article
Physiological aspects
Public Health
Reduction
Signal Transduction - drug effects
United Kingdom > UK
United States > US
Online AccessGet full text

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Abstract Background/Objectives: Short-chain fatty acids, produced by microbiome fermentation of carbohydrates, have been linked to a reduction in appetite, body weight and adiposity. However, determining the contribution of central and peripheral mechanisms to these effects has not been possible. Subjects/Methods: C57BL/6 mice fed with either normal or high-fat diet were treated with nanoparticle-delivered acetate, and the effects on metabolism were investigated. Results: In the liver, acetate decreased lipid accumulation and improved hepatic function, as well as increasing mitochondrial efficiency. In white adipose tissue, it inhibited lipolysis and induced 'browning', increasing thermogenic capacity that led to a reduction in body adiposity. Conclusions: This study provides novel insights into the peripheral mechanism of action of acetate, independent of central action, including ‘browning’ and enhancement of hepatic mitochondrial function.
AbstractList Background/Objectives:Short-chain fatty acids, produced by microbiome fermentation of carbohydrates, have been linked to a reduction in appetite, body weight and adiposity. However, determining the contribution of central and peripheral mechanisms to these effects has not been possible.Subjects/Methods:C57BL/6 mice fed with either normal or high-fat diet were treated with nanoparticle-delivered acetate, and the effects on metabolism were investigated.Results:In the liver, acetate decreased lipid accumulation and improved hepatic function, as well as increasing mitochondrial efficiency. In white adipose tissue, it inhibited lipolysis and induced 'browning', increasing thermogenic capacity that led to a reduction in body adiposity.Conclusions:This study provides novel insights into the peripheral mechanism of action of acetate, independent of central action, including ‘browning’ and enhancement of hepatic mitochondrial function.
SUBJECTS/METHODS: C57BL/6 mice fed with either normal or high-fat diet were treated with nanoparticle-delivered acetate, and the effects on metabolism were investigated. International Journal of Obesity (2016) 40, 955-963; doi:10.1038/ijo.2016.23
BACKGROUND/OBJECTIVES: Short-chain fatty acids, produced by microbiome fermentation of carbohydrates, have been linked to a reduction in appetite, body weight and adiposity. However, determining the contribution of central and peripheral mechanisms to these effects has not been possible. SUBJECTS/METHODS: C57BL/6 mice fed with either normal or high-fat diet were treated with nanoparticle-delivered acetate, and the effects on metabolism were investigated. RESULTS: In the liver, acetate decreased lipid accumulation and improved hepatic function, as well as increasing mitochondrial efficiency. In white adipose tissue, it inhibited lipolysis and induced 'browning', increasing thermogenic capacity that led to a reduction in body adiposity. CONCLUSIONS: This study provides novel insights into the peripheral mechanism of action of acetate, independent of central action, including 'browning' and enhancement of hepatic mitochondrial function. International Journal of Obesity (2016) 40, 955-963; doi:10.1038/ijo.2016.23
Background/Objectives: Short-chain fatty acids, produced by microbiome fermentation of carbohydrates, have been linked to a reduction in appetite, body weight and adiposity. However, determining the contribution of central and peripheral mechanisms to these effects has not been possible. Subjects/Methods: C57BL/6 mice fed with either normal or high-fat diet were treated with nanoparticle-delivered acetate, and the effects on metabolism were investigated. Results: In the liver, acetate decreased lipid accumulation and improved hepatic function, as well as increasing mitochondrial efficiency. In white adipose tissue, it inhibited lipolysis and induced 'browning', increasing thermogenic capacity that led to a reduction in body adiposity. Conclusions: This study provides novel insights into the peripheral mechanism of action of acetate, independent of central action, including 'browning' and enhancement of hepatic mitochondrial function. International Journal of Obesity (2016) 40, 955-963; doi: 10.1038/ijo.2016.23; published online 15 March 2016
Short-chain fatty acids, produced by microbiome fermentation of carbohydrates, have been linked to a reduction in appetite, body weight and adiposity. However, determining the contribution of central and peripheral mechanisms to these effects has not been possible. In the liver, acetate decreased lipid accumulation and improved hepatic function, as well as increasing mitochondrial efficiency. In white adipose tissue, it inhibited lipolysis and induced 'browning', increasing thermogenic capacity that led to a reduction in body adiposity. This study provides novel insights into the peripheral mechanism of action of acetate, independent of central action, including 'browning' and enhancement of hepatic mitochondrial function.
BACKGROUND/OBJECTIVESShort-chain fatty acids, produced by microbiome fermentation of carbohydrates, have been linked to a reduction in appetite, body weight and adiposity. However, determining the contribution of central and peripheral mechanisms to these effects has not been possible.SUBJECTS/METHODSC57BL/6 mice fed with either normal or high-fat diet were treated with nanoparticle-delivered acetate, and the effects on metabolism were investigated.RESULTSIn the liver, acetate decreased lipid accumulation and improved hepatic function, as well as increasing mitochondrial efficiency. In white adipose tissue, it inhibited lipolysis and induced 'browning', increasing thermogenic capacity that led to a reduction in body adiposity.CONCLUSIONSThis study provides novel insights into the peripheral mechanism of action of acetate, independent of central action, including 'browning' and enhancement of hepatic mitochondrial function.
Background/Objectives: Short-chain fatty acids, produced by microbiome fermentation of carbohydrates, have been linked to a reduction in appetite, body weight and adiposity. However, determining the contribution of central and peripheral mechanisms to these effects has not been possible. Subjects/Methods: C57BL/6 mice fed with either normal or high-fat diet were treated with nanoparticle-delivered acetate, and the effects on metabolism were investigated. Results: In the liver, acetate decreased lipid accumulation and improved hepatic function, as well as increasing mitochondrial efficiency. In white adipose tissue, it inhibited lipolysis and induced 'browning', increasing thermogenic capacity that led to a reduction in body adiposity. Conclusions: This study provides novel insights into the peripheral mechanism of action of acetate, independent of central action, including ‘browning’ and enhancement of hepatic mitochondrial function.
Short-chain fatty acids, produced by microbiome fermentation of carbohydrates, have been linked to a reduction in appetite, body weight and adiposity. However, determining the contribution of central and peripheral mechanisms to these effects has not been possible. C57BL/6 mice fed with either normal or high-fat diet were treated with nanoparticle-delivered acetate, and the effects on metabolism were investigated. In the liver, acetate decreased lipid accumulation and improved hepatic function, as well as increasing mitochondrial efficiency. In white adipose tissue, it inhibited lipolysis and induced 'browning', increasing thermogenic capacity that led to a reduction in body adiposity. This study provides novel insights into the peripheral mechanism of action of acetate, independent of central action, including 'browning' and enhancement of hepatic mitochondrial function.
Audience Academic
Author Navaratnam, N
Sahuri-Arisoylu, M
Frost, G
Brody, L P
Bell, J D
Miller, A D
Parkes, H
Thomas, E L
Parkinson, J R
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– sequence: 2
  givenname: L P
  surname: Brody
  fullname: Brody, L P
  organization: Division of Diabetes, Department of Investigative Medicine, Nutrition and Dietetic Research Group, Endocrinology and Metabolism, Imperial College London, Hammersmith Hospital
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  givenname: J R
  surname: Parkinson
  fullname: Parkinson, J R
  organization: Department of Life Sciences, Faculty of Science and Technology, University of Westminster
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  surname: Parkes
  fullname: Parkes, H
  organization: CR-UK Clinical MR Research Group, Institute of Cancer Research
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  fullname: Navaratnam, N
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  fullname: Miller, A D
  organization: Institute of Pharmaceutical Science, King's College London
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  fullname: Thomas, E L
  organization: Department of Life Sciences, Faculty of Science and Technology, University of Westminster
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  givenname: G
  surname: Frost
  fullname: Frost, G
  organization: Division of Diabetes, Department of Investigative Medicine, Nutrition and Dietetic Research Group, Endocrinology and Metabolism, Imperial College London, Hammersmith Hospital
– sequence: 9
  givenname: J D
  surname: Bell
  fullname: Bell, J D
  email: J.Bell@westminster.ac.uk
  organization: Department of Life Sciences, Faculty of Science and Technology, University of Westminster
BackLink https://www.ncbi.nlm.nih.gov/pubmed/26975441$$D View this record in MEDLINE/PubMed
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ContentType Journal Article
Copyright Macmillan Publishers Limited 2016
COPYRIGHT 2016 Nature Publishing Group
Copyright Nature Publishing Group Jun 2016
Macmillan Publishers Limited 2016.
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Snippet Background/Objectives: Short-chain fatty acids, produced by microbiome fermentation of carbohydrates, have been linked to a reduction in appetite, body weight...
Short-chain fatty acids, produced by microbiome fermentation of carbohydrates, have been linked to a reduction in appetite, body weight and adiposity. However,...
BACKGROUND/OBJECTIVES: Short-chain fatty acids, produced by microbiome fermentation of carbohydrates, have been linked to a reduction in appetite, body weight...
Background/Objectives: Short-chain fatty acids, produced by microbiome fermentation of carbohydrates, have been linked to a reduction in appetite, body weight...
SUBJECTS/METHODS: C57BL/6 mice fed with either normal or high-fat diet were treated with nanoparticle-delivered acetate, and the effects on metabolism were...
Background/Objectives:Short-chain fatty acids, produced by microbiome fermentation of carbohydrates, have been linked to a reduction in appetite, body weight...
BACKGROUND/OBJECTIVESShort-chain fatty acids, produced by microbiome fermentation of carbohydrates, have been linked to a reduction in appetite, body weight...
Background/ Objectives: Short-chain fatty acids, produced by microbiome fermentation of carbohydrates, have been linked to a reduction in appetite, body weight...
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pubmed
crossref
springer
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StartPage 955
SubjectTerms 38/39
59/57
631/443/319/2723
631/443/319/333/1465
64/60
82/80
Accumulation
Acetic acid
Acetic Acid - chemistry
Adipocytes, Brown - drug effects
Adipocytes, Brown - metabolism
Adipogenesis - drug effects
Adipose tissue
Adipose Tissue - drug effects
Adipose Tissue - metabolism
Adipose Tissue, White - drug effects
Adipose Tissue, White - metabolism
Adipose tissues
Analysis
Animals
Appetite
Body fat
Body weight
Browning
Carbohydrates
Diet
Disease Models, Animal
Epidemiology
Fatty acids
Fatty Acids - chemistry
Fatty Acids - pharmacology
Fermentation
Health aspects
Health Promotion and Disease Prevention
High fat diet
Internal Medicine
Kinases
Life sciences
Lipid Metabolism - drug effects
Lipids
Lipolysis
Liver
Liver - drug effects
Liver - metabolism
Male
Medical research
Medicine
Medicine & Public Health
Metabolic Diseases
Metabolism
Mice
Mice, Inbred C57BL
Microbiomes
Mitochondria
Mitochondrial DNA
Nanoparticles
original-article
Physiological aspects
Public Health
Reduction
Signal Transduction - drug effects
Title Reprogramming of hepatic fat accumulation and 'browning' of adipose tissue by the short-chain fatty acid acetate
URI https://link.springer.com/article/10.1038/ijo.2016.23
https://www.ncbi.nlm.nih.gov/pubmed/26975441
https://www.proquest.com/docview/1794123860
https://www.proquest.com/docview/2639130562
https://www.proquest.com/docview/1795860258
https://www.proquest.com/docview/1808708034
Volume 40
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