Determination of Acid Dissociation Constant of Pravastatin under Degraded Conditions by Capillary Zone Electrophoresis

• Published in: Analytical Sciences Vol. 31; no. 11; pp. 1193 - 1196
• Main Authors: TAKAYANAGI, Toshio, AMIYA, Mika, SHIMAKAMI, Natsumi, YABUTANI, Tomoki
• Format: Journal Article
• Language: English
• Published: Singapore The Japan Society for Analytical Chemistry 2015; Springer Nature Singapore; Nature Publishing Group
• Subjects: acid degradation; acid dissociation constant; Analytical Chemistry; Capillarity; Capillary zone; capillary zone electrophoresis; Chemistry; Constants; Degradation; Electrophoresis; Electrophoresis, Capillary - methods; Hydrogen-Ion Concentration; Mathematical analysis; micellar electrokinetic chromatography; Pravastatin; Pravastatin - chemistry; Time Factors; capillary zone electrophoresis; micellar electrokinetic chromatography; acid dissociation constant; Pravastatin; acid degradation

The acid dissociation constant of pravastatin was determined under degraded conditions. Pravastatin was degraded in an acidic solution (pH = 2.0) for 5 h, and the degradation solution was subjected to the measurement of the effective electrophoretic mobility by capillary zone electrophoresis. Althou...