Determination of Acid Dissociation Constant of Pravastatin under Degraded Conditions by Capillary Zone Electrophoresis

The acid dissociation constant of pravastatin was determined under degraded conditions. Pravastatin was degraded in an acidic solution (pH = 2.0) for 5 h, and the degradation solution was subjected to the measurement of the effective electrophoretic mobility by capillary zone electrophoresis. Althou...

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Published inAnalytical Sciences Vol. 31; no. 11; pp. 1193 - 1196
Main Authors TAKAYANAGI, Toshio, AMIYA, Mika, SHIMAKAMI, Natsumi, YABUTANI, Tomoki
Format Journal Article
LanguageEnglish
Published Singapore The Japan Society for Analytical Chemistry 2015
Springer Nature Singapore
Nature Publishing Group
Subjects
acid degradation
acid dissociation constant
Analytical Chemistry
Capillarity
Capillary zone
capillary zone electrophoresis
Chemistry
Constants
Degradation
Electrophoresis
Electrophoresis, Capillary - methods
Hydrogen-Ion Concentration
Mathematical analysis
micellar electrokinetic chromatography
Pravastatin
Pravastatin - chemistry
Time Factors
capillary zone electrophoresis
micellar electrokinetic chromatography
acid dissociation constant
Pravastatin
acid degradation
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Abstract The acid dissociation constant of pravastatin was determined under degraded conditions. Pravastatin was degraded in an acidic solution (pH = 2.0) for 5 h, and the degradation solution was subjected to the measurement of the effective electrophoretic mobility by capillary zone electrophoresis. Although the amount of pravastatin decreased by the acid degradation, its acid dissociation constant was successfully determined with the residual pravastatin through its effective electrophoretic mobility. The determined acid dissociation constant value agreed well with the one obtained with freshly prepared solution and with some reported values.
AbstractList The acid dissociation constant of pravastatin was determined under degraded conditions. Pravastatin was degraded in an acidic solution (pH = 2.0) for 5 h, and the degradation solution was subjected to the measurement of the effective electrophoretic mobility by capillary zone electrophoresis. Although the amount of pravastatin decreased by the acid degradation, its acid dissociation constant was successfully determined with the residual pravastatin through its effective electrophoretic mobility. The determined acid dissociation constant value agreed well with the one obtained with freshly prepared solution and with some reported values.
The acid dissociation constant of pravastatin was determined under degraded conditions. Pravastatin was degraded in an acidic solution (pH = 2.0) for 5 h, and the degradation solution was subjected to the measurement of the effective electrophoretic mobility by capillary zone electrophoresis. Although the amount of pravastatin decreased by the acid degradation, its acid dissociation constant was successfully determined with the residual pravastatin through its effective electrophoretic mobility. The determined acid dissociation constant value agreed well with the one obtained with freshly prepared solution and with some reported values.The acid dissociation constant of pravastatin was determined under degraded conditions. Pravastatin was degraded in an acidic solution (pH = 2.0) for 5 h, and the degradation solution was subjected to the measurement of the effective electrophoretic mobility by capillary zone electrophoresis. Although the amount of pravastatin decreased by the acid degradation, its acid dissociation constant was successfully determined with the residual pravastatin through its effective electrophoretic mobility. The determined acid dissociation constant value agreed well with the one obtained with freshly prepared solution and with some reported values.
Author SHIMAKAMI, Natsumi
TAKAYANAGI, Toshio
AMIYA, Mika
YABUTANI, Tomoki
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  organization: Department of Life System, Institute of Technology and Science, Tokushima University
BackLink https://www.ncbi.nlm.nih.gov/pubmed/26561266$$D View this record in MEDLINE/PubMed
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Cites_doi 10.1246/cl.2001.14
10.1111/j.1440-1746.1996.tb01706.x
10.1016/S0731-7085(00)00372-1
10.1002/jps.10087
10.2116/bunsekikagaku.64.105
10.1016/S0731-7085(03)00238-3
10.1002/jps.2600800905
10.1021/ac00017a029
10.2116/bunsekikagaku.63.643
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Keywords capillary zone electrophoresis
micellar electrokinetic chromatography
acid dissociation constant
Pravastatin
acid degradation
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SubjectTerms acid degradation
acid dissociation constant
Analytical Chemistry
Capillarity
Capillary zone
capillary zone electrophoresis
Chemistry
Constants
Degradation
Electrophoresis
Electrophoresis, Capillary - methods
Hydrogen-Ion Concentration
Mathematical analysis
micellar electrokinetic chromatography
Pravastatin
Pravastatin - chemistry
Time Factors
Title Determination of Acid Dissociation Constant of Pravastatin under Degraded Conditions by Capillary Zone Electrophoresis
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