Sensitive Analysis of Blonanserin, a Novel Antipsychotic Agent, in Human Plasma by Ultra-Performance Liquid Chromatography–Tandem Mass Spectrometry

• Published in: Analytical Sciences Vol. 26; no. 10; pp. 1099 - 1102
• Main Authors: OGAWA, Tadashi, HATTORI, Hideki, KANEKO, Rina, ITO, Kenjiro, IWAI, Masayo, MIZUTANI, Yoko, ARINOBU, Tetsuya, ISHII, Akira, SUZUKI, Osamu, SENO, Hiroshi
• Format: Journal Article
• Language: English
• Published: Singapore The Japan Society for Analytical Chemistry 2010; Springer Nature Singapore; Japan Science and Technology Agency
• Subjects: Analytical Chemistry; Antipsychotic Agents - blood; Chemistry; Chromatography, High Pressure Liquid; Humans; Mass Spectrometry; Piperazines - blood; Piperidines - blood; Reproducibility of Results; Sensitivity and Specificity; Solid Phase Microextraction; Tandem Mass Spectrometry
• ISSN: 0910-6340; 1348-2246; 1348-2246
• DOI: 10.2116/analsci.26.1099

A rapid and sensitive method for analysis of blonanserin in human plasma by ultra-performance liquid chromatography-tandem mass spectrometry is presented. After pretreatment of a plasma sample by solid-phase extraction, blonanserin was analyzed by the system with a C18 column. This method gave satisfactory recovery rates, reproducibility, and good linearity of calibration curve in the range of 0.01 – 10.0 ng/mL for quality control samples spiked with blonanserin. The detection limit was as low as 1 pg/mL. This method seems very useful in forensic and clinical toxicology and pharmacokinetic studies.