Multiple testing for neuroimaging via hidden Markov random field

• Published in: Biometrics Vol. 71; no. 3; pp. 741 - 750
• Main Authors: Shu, Hai, Nan, Bin, Koeppe, Robert
• Format: Journal Article
• Language: English
• Published: England Blackwell Publishing Ltd 01.09.2015; International Biometric Society
• Subjects: Algorithms; Alzheimer disease; Alzheimer Disease - diagnostic imaging; Alzheimer's disease; BIOMETRIC METHODOLOGY; biometry; Cognitive Dysfunction - diagnostic imaging; Computer Simulation; False discovery rate; Fluorodeoxyglucose F18; Generalized expectation-maximization algorithm; Humans; image analysis; Image Interpretation, Computer-Assisted - methods; Imaging, Three-Dimensional - methods; Ising model; Local significance index; Markov analysis; Markov chain; Markov Chains; Medical imaging; Models, Statistical; Neuroimaging - methods; Penalized likelihood; Positron-Emission Tomography - methods; Radiopharmaceuticals; Reproducibility of Results; risk; Sensitivity and Specificity; False discovery rate; Ising model; Local significance index; Alzheimer's disease; Penalized likelihood; Generalized expectation-maximization algorithm
• ISSN: 0006-341X; 1541-0420
• DOI: 10.1111/biom.12329

Traditional voxel-level multiple testing procedures in neuroimaging, mostly p-value based, often ignore the spatial correlations among neighboring voxels and thus suffer from substantial loss of power. We extend the local-significance-index based procedure originally developed for the hidden Markov chain models, which aims to minimize the false nondiscovery rate subject to a constraint on the false discovery rate, to three-dimensional neuroimaging data using a hidden Markov random field model. A generalized expectation–maximization algorithm for maximizing the penalized likelihood is proposed for estimating the model parameters. Extensive simulations show that the proposed approach is more powerful than conventional false discovery rate procedures. We apply the method to the comparison between mild cognitive impairment, a disease status with increased risk of developing Alzheimer's or another dementia, and normal controls in the FDG-PET imaging study of the Alzheimer's Disease Neuroimaging Initiative.