The microbiome revolution

The collection of bacteria, viruses, and fungi that live in and on the human body, collectively known as the microbiome, has recently emerged as an important factor in human physiology and disease. The gut in particular is a biological niche that is home to a diverse array of microbes that influence...

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Bibliographic Details
Published inThe Journal of clinical investigation Vol. 124; no. 10; pp. 4162 - 4165
Main Author Blaser, Martin J
Format Journal Article
LanguageEnglish
Published United States American Society for Clinical Investigation 01.10.2014
Subjects
Analysis
Anti-Bacterial Agents - therapeutic use
Biological products
Biomedical research
Carcinogenesis
Clostridium difficile - metabolism
Gastrointestinal Tract - microbiology
Health aspects
Host-bacteria relationships
Humans
Immunity
Inflammation
Inflammatory bowel disease
Metabolism
Microbial Interactions
Microbiota
Microbiota (Symbiotic organisms)
Pharmaceutical Preparations - chemistry
Physiology
Probiotics - chemistry
Review Series
Scientists
Studies
Xenobiotics - chemistry
United States
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Summary:The collection of bacteria, viruses, and fungi that live in and on the human body, collectively known as the microbiome, has recently emerged as an important factor in human physiology and disease. The gut in particular is a biological niche that is home to a diverse array of microbes that influence nearly all aspects of human biology through their interactions with their host; new technologies are beginning to reveal important aspects of host-microbe interactions. Articles in this Review series address how perturbations of the microbiota, such as through antibiotic use, influence its overall structure and function; how our microbiome influences the impact of infectious agents, such as C. difficile; how our microbiome mediates metabolism of xenobiotics; how the microbiota contribute to immunity as well as to metabolic and inflammatory diseases; and the role of commensal microbes in oncogenesis.
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ISSN:0021-9738
1558-8238
DOI:10.1172/JCI78366