Vertical Sleeve Gastrectomy Is Effective in Two Genetic Mouse Models of Glucagon-Like Peptide 1 Receptor Deficiency

• Published in: Diabetes (New York, N.Y.) Vol. 62; no. 7; pp. 2380 - 2385
• Main Authors: Wilson-Pérez, Hilary E., Chambers, Adam P., Ryan, Karen K., Li, Bailing, Sandoval, Darleen A., Stoffers, Doris, Drucker, Daniel J., Pérez-Tilve, Diego, Seeley, Randy J.
• Format: Journal Article
• Language: English
• Published: Alexandria, VA American Diabetes Association 01.07.2013
• Subjects: Animals; Biological and medical sciences; Body Composition - drug effects; Body Composition - physiology; Body Weight - drug effects; Body Weight - physiology; Cell receptors; Diabetes. Impaired glucose tolerance; Eating - drug effects; Eating - physiology; Endocrine pancreas. Apud cells (diseases); Endocrinopathies; Etiopathogenesis. Screening. Investigations. Target tissue resistance; Gastrectomy; Gastrectomy - methods; Genetic aspects; Glucagon-Like Peptide 1 - metabolism; Glucagon-Like Peptide-1 Receptor; Glucose metabolism; Insulin Resistance - physiology; Medical sciences; Mice; Mice, Knockout; Obesity - genetics; Obesity - metabolism; Obesity - surgery; Original Research; Peptides - pharmacology; Physiological aspects; Postprandial Period; Receptors, Glucagon - genetics; Receptors, Glucagon - metabolism; Venoms - pharmacology; Canada; Endocrinopathy; Animal model; Diabetes mellitus; Deficiency; Rodentia; Gastrectomy; Glucagon like peptide 1; Vertebrata; Gastrointestinal hormone; Mammalia; Mouse; Animal; Genetics; Biological receptor
• ISSN: 0012-1797; 1939-327X; 1939-327X
• DOI: 10.2337/db12-1498

Glucagon-like peptide 1 (GLP-1) is a peptide hormone that is released from the gut in response to nutrient ingestion and that has a range of metabolic effects, including enhancing insulin secretion and decreasing food intake. Postprandial GLP-1 secretion is greatly enhanced in rats and humans after some bariatric procedures, including vertical sleeve gastrectomy (VSG), and has been widely hypothesized to contribute to reduced intake, weight loss, and the improvements in glucose homeostasis after VSG. We tested this hypothesis using two separate models of GLP-1 receptor deficiency. We found that VSG-operated GLP-1 receptor–deficient mice responded similarly to wild-type controls in terms of body weight and body fat loss, improved glucose tolerance, food intake reduction, and altered food selection. These data demonstrate that GLP-1 receptor activity is not necessary for the metabolic improvements induced by VSG surgery.