Regulation of Fasted Blood Glucose by Resistin

• Published in: Science (American Association for the Advancement of Science) Vol. 303; no. 5661; pp. 1195 - 1198
• Main Authors: Banerjee, Ronadip R., Rangwala, Shamina M., Shapiro, Jennifer S., Rich, A. Sophie, Rhoades, Ben, Qi, Yong, Wang, Juan, Rajala, Michael W., Pocai, Alessandro, Scherer, Phillipp E., Steppan, Claire M., Ahima, Rexford S., Obici, Silvana, Rossetti, Luciano, Lazar, Mitchell A.
• Format: Journal Article
• Language: English
• Published: Washington, DC American Association for the Advancement of Science 20.02.2004; The American Association for the Advancement of Science
• Subjects: Adipocytes; Adipocytes - metabolism; AMP-Activated Protein Kinases; Animals; Biological and medical sciences; Blood glucose; Blood Glucose - metabolism; Blood sugar; Body Weight; Coding; Diabetes; Diet; Dietary Fats - administration & dosage; Fasting; Gene Targeting; Gluconeogenesis; Glucose; Glucose Tolerance Test; Glucose-6-Phosphatase - metabolism; High fat diet; Homeostasis; Hormones, Ectopic - administration & dosage; Hormones, Ectopic - blood; Hormones, Ectopic - genetics; Hormones, Ectopic - physiology; Hyperglycemia; Insulin - blood; Insulin resistance; Liver; Liver - metabolism; Male; Medical sciences; Metabolic diseases; Metabolism; Mice; Multienzyme Complexes - metabolism; Obesity; Obesity - metabolism; Phosphoenolpyruvate Carboxykinase (GTP) - metabolism; Physiological aspects; Protein-Serine-Threonine Kinases - metabolism; Recombinant Proteins - administration & dosage; Resistin; Rodents; Scientific Concepts; Signal Transduction; Type 2 diabetes mellitus; United States; Endocrinopathy; Adipocyte; Animal model; Obesity; Fasting; Diabetes mellitus; Liver; Peptide hormone; Rodentia; Glucose; Resistine; Metabolic disorder; Vertebrata; Hyperglycemia; Mammalia; Mouse; Complication; Glycemia
• ISSN: 0036-8075; 1095-9203
• DOI: 10.1126/science.1092341

The association between obesity and diabetes supports an endocrine role for the adipocyte in maintaining glucose homeostasis. Here we report that mice lacking the adipocyte hormone resistin exhibit low blood glucose levels after fasting, due to reduced hepatic glucose production. This is partly mediated by activation of adenosine monophosphate-activated protein kinase and decreased expression of gluconeogenic enzymes in the liver. The data thus support a physiological function for resistin in the maintenance of blood glucose during fasting. Remarkably, lack of resistin diminishes the increase in post-fast blood glucose normally associated with increased weight, suggesting a role for resistin in mediating hyperglycemia associated with obesity.