Carbosulfonylation of Alkynes: A Direct Conversion of sp-C to sp 3 -C through Visible Light-Mediated 3-Component Reaction
A 3-component metal-free carbosulfonylation of alkynes is reported using readily available alkyl carboxylic acids and arylsulfinates under visible light irradiation. This photochemical approach gives direct conversion of sp-C to sp -C yielding highly functionalized alkyl sulfones. It employs feedsto...
Saved in:
Published in | Organic letters Vol. 26; no. 37; pp. 7858 - 7863 |
---|---|
Main Authors | , , |
Format | Journal Article |
Language | English |
Published |
United States
20.09.2024
|
Online Access | Get full text |
Cover
Loading…
Summary: | A 3-component metal-free carbosulfonylation of alkynes is reported using readily available alkyl carboxylic acids and arylsulfinates under visible light irradiation. This photochemical approach gives direct conversion of sp-C to sp
-C yielding highly functionalized alkyl sulfones. It employs feedstock chemicals as starting materials and shows a broad substrate scope and moderate diastereoselectivity. The method's utility is highlighted in the synthesis of sedum alkaloids. A single photocatalyst is proposed to be active in two distinct photocatalytic cycles operating in tandem. |
---|---|
ISSN: | 1523-7060 1523-7052 |
DOI: | 10.1021/acs.orglett.4c02700 |