Clinical use of lithium salts: guide for users and prescribers

Background Lithium has been used clinically for 70 years, mainly to treat bipolar disorder. Competing treatments and exaggerated impressions about complexity and risks of lithium treatment have led to its declining use in some countries, encouraging this update about its safe clinical use. We conduc...

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Published inInternational Journal of Bipolar Disorders Vol. 7; no. 1; pp. 16 - 10
Main Authors Tondo, Leonardo, Alda, Martin, Bauer, Michael, Bergink, Veerle, Grof, Paul, Hajek, Tomas, Lewitka, Ute, Licht, Rasmus W., Manchia, Mirko, Müller-Oerlinghausen, Bruno, Nielsen, René E., Selo, Marylou, Simhandl, Christian, Baldessarini, Ross J.
Format Journal Article
LanguageEnglish
Published Berlin/Heidelberg Springer Berlin Heidelberg 22.07.2019
Springer Nature B.V
SpringerOpen
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Summary:Background Lithium has been used clinically for 70 years, mainly to treat bipolar disorder. Competing treatments and exaggerated impressions about complexity and risks of lithium treatment have led to its declining use in some countries, encouraging this update about its safe clinical use. We conducted a nonsystematic review of recent research reports and developed consensus among international experts on the use of lithium to treat major mood disorders, aiming for a simple but authoritative guide for patients and prescribers. Main text We summarized recommendations concerning safe clinical use of lithium salts to treat major mood disorders, including indications, dosing, clinical monitoring, adverse effects and use in specific circumstances including during pregnancy and for the elderly. Conclusions Lithium continues as the standard and most extensively evaluated treatment for bipolar disorder, especially for long-term prophylaxis.
Bibliography:ObjectType-Article-2
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ISSN:2194-7511
2194-7511
DOI:10.1186/s40345-019-0151-2