TASSEL: software for association mapping of complex traits in diverse samples

Association analyses that exploit the natural diversity of a genome to map at very high resolutions are becoming increasingly important. In most studies, however, researchers must contend with the confounding effects of both population and family structure. TASSEL (Trait Analysis by aSSociation, Evo...

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Bibliographic Details
Published inBioinformatics Vol. 23; no. 19; pp. 2633 - 2635
Main Authors Bradbury, Peter J., Zhang, Zhiwu, Kroon, Dallas E., Casstevens, Terry M., Ramdoss, Yogesh, Buckler, Edward S.
Format Journal Article
LanguageEnglish
Published Oxford Oxford University Press 01.10.2007
Oxford Publishing Limited (England)
Subjects
Algorithms
Biological and medical sciences
Chromosome Mapping - methods
Data Interpretation, Statistical
DNA Mutational Analysis - methods
Fundamental and applied biological sciences. Psychology
General aspects
Genetic Variation - genetics
Linkage Disequilibrium - genetics
Mathematics in biology. Statistical analysis. Models. Metrology. Data processing in biology (general aspects)
Quantitative Trait Loci - genetics
Software
Software
Polygenic
Bioinformatics
Sample
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Summary:Association analyses that exploit the natural diversity of a genome to map at very high resolutions are becoming increasingly important. In most studies, however, researchers must contend with the confounding effects of both population and family structure. TASSEL (Trait Analysis by aSSociation, Evolution and Linkage) implements general linear model and mixed linear model approaches for controlling population and family structure. For result interpretation, the program allows for linkage disequilibrium statistics to be calculated and visualized graphically. Database browsing and data importation is facilitated by integrated middleware. Other features include analyzing insertions/deletions, calculating diversity statistics, integration of phenotypic and genotypic data, imputing missing data and calculating principal components. Availability: The TASSEL executable, user manual, example data sets and tutorial document are freely available at http://www.maizegenetics.net/tassel. The source code for TASSEL can be found at http://sourceforge.net/projects/tassel. Contact: pjb39@cornell.edu
Bibliography:To whom correspondence should be addressed.
ark:/67375/HXZ-GX9H6K2J-W
Associate Editor: Martin Bishop
istex:6A5FF3FC22531CA83FA0D23C371C7EB93CE25B10
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ISSN:1367-4803
1460-2059
1367-4811
DOI:10.1093/bioinformatics/btm308