Usefulness of Uric Acid to Predict Changes in C-Reactive Protein and Interleukin-6 in 3-Year Period in Italians Aged 21 to 98 Years

• Published in: The American journal of cardiology Vol. 100; no. 1; pp. 115 - 121
• Main Authors: Ruggiero, Carmelinda, MD, Cherubini, Antonio, MD, PhD, Miller, Edgar, MD, Maggio, Marcello, MD, PhD, Najjar, Samer S., MD, Lauretani, Fulvio, MD, Bandinelli, Stefania, MD, Senin, Umberto, MD, Ferrucci, Luigi, MD, PhD
• Format: Journal Article
• Language: English
• Published: New York, NY Elsevier Inc 01.07.2007; Elsevier; Elsevier Limited
• Subjects: Acids; Adult; Aged; Aged, 80 and over; Antioxidants; Atherosclerosis - blood; Atherosclerosis - etiology; Biological and medical sciences; C-Reactive Protein - analysis; Cardiology; Cardiology. Vascular system; Cardiovascular; Cardiovascular disease; Cardiovascular Diseases - blood; Cohort Studies; Female; Follow-Up Studies; Humans; Interleukin-6 - blood; Italy; Male; Medical sciences; Middle Aged; Predictive Value of Tests; Proteins; Risk factors; Thrombosis - blood; Thrombosis - etiology; Time Factors; Uric Acid - blood; Italy; Europe; Interleukin 6; Italian; Interleukin 3; Prediction; Period; Circulatory system; Change; Uric acid; Cardiology; C reactive protein; Phlebology
• ISSN: 0002-9149; 1879-1913
• DOI: 10.1016/j.amjcard.2007.02.065

The role of uric acid (UA) in the process of atherothrombosis is controversial. Although serum UA has powerful antioxidant properties, epidemiological studies showed that UA was a risk factor for cardiovascular diseases and was positively associated with proinflammatory markers. Relations between baseline UA and changes in UA circulating levels with C-reactive protein (CRP) and interleukin-6 (IL-6) after 3 years of follow-up in a cohort of 892 Italian men and women aged 21 to 98 years was investigated. Subjects had complete baseline and follow-up data for UA, inflammatory markers, and covariates. An autoregressive approach was used to study such a relation. In adjusted analyses, baseline UA and changes in UA predicted a 3-year change in CRP (p = 0.028), but not IL-6 (p = 0.101). The relation between UA and CRP persisted after adjustment for baseline IL-6. Subjects with high UA at baseline had a progressively higher probability of developing clinically relevant increased IL-6 (>2.5 pg/ml) and CRP (>3 mg/L) during 3 years. In conclusion, our study suggests that in a population-based cohort, baseline UA and changes in circulating UA during 3 years of follow-up predict changes in circulating CRP independent of relevant confounders, including baseline IL-6.