Process of Hypertrophic Scar Formation： Expression of Eukaryotic Initiation Factor 6

• Published in: Chinese medical journal Vol. 128; no. 20; pp. 2787 - 2791
• Main Authors: Yang, Qing-Qing, Yang, Si-Si, Tan, Jiang-Lin, Luo, Gao-Xing, He, Wei-Feng, Wu, Jun
• Format: Journal Article
• Language: English
• Published: China Medknow Publications Pvt Ltd 20.10.2015; Medknow Publications and Media Pvt. Ltd; Lippincott Williams & Wilkins Ovid Technologies; Institute of Burn Research; Medknow Publications & Media Pvt Ltd; Wolters Kluwer
• Subjects: Adult; Age; Apoptosis; Blotting, Western; Care and treatment; Cell cycle; Cicatrices; Cicatrix, Hypertrophic - metabolism; Disease; Eukaryotic Initiation Factor 6; Hypertrophic Scar; Therapeutic Target; Female; Gene Expression Regulation - genetics; Genetic aspects; Hospitals; Humans; Immunohistochemistry; Laboratories; Male; Middle Aged; Original; Pain; Peptide Initiation Factors - metabolism; Polyclonal antibodies; Pregnancy; Proteins; Proteomics; Retrospective Studies; Risk factors; Rodents; Trauma; Western印迹; Young Adult; 免疫组织化学; 分子机制; 因子; 增生性瘢痕; 真核; 蛋白表达; 靶分子; China; Therapeutic Target; Eukaryotic Initiation Factor 6; Hypertrophic Scar
• ISSN: 0366-6999; 2542-5641; 2542-5641
• DOI: 10.4103/0366-6999.167359

Background： Hypertrophic scar is one of the most common complications and often causes the disfigurement or deformity in bum or trauma patients. Therapeutic methods on hypertrophic scar treatment have limitations due to the poor understanding of mechanisms of hypertrophic scar formation. To throw light on the molecular mechanism of hypertrophic scar formation will definitely improve the outcome of the treatment. This study aimed to illustrate the negative role of eukaryotic initiation factor 6 （elF6） in the process of human hypertrophic scar tbrmation, and provide a possible indicator of hypertrophic scar treatment and a potential target molecule for hypertrophic scar. Methods： In the present study, we investigated the protein expression of elF6 in the human hypertrophic scar of different periods by immunohistochemistry and Western blot analysis. Results： In the hypertrophic scar tissue, elF6 expression was significantly decreased and absent in the basal layer of epidermis in the early period, and increased slowly and began to appear in the basal layer of epidermis by the scar formation time. Conclusions： This study confirmed that elF6 expression was significantly related to the development of hypertrophic scar, and the elF6 may be a target molecule for hypertrophic scar control or could be an indicator of the outcomes for other treatment modalities.