Tuning the Composition of AuPt Bimetallic Nanoparticles for Antibacterial Application

We show that bimetallic nanoparticles (NPs) of AuPt without any surface modification are potent antibiotic reagents, while pure Au NPs or pure Pt NPs display no antibiotic activities. The most potent antibacterial AuPt NPs happen to be the most effective catalysts for chemical transformations. The m...

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Published inAngewandte Chemie International Edition Vol. 53; no. 31; pp. 8127 - 8131
Main Authors Zhao, Yuyun, Ye, Chunjie, Liu, Wenwen, Chen, Rong, Jiang, Xingyu
Format Journal Article
LanguageEnglish
Published Weinheim WILEY-VCH Verlag 28.07.2014
WILEY‐VCH Verlag
Wiley Subscription Services, Inc
EditionInternational ed. in English
Subjects
Adenosine triphosphate
Anti-Bacterial Agents - chemistry
Anti-Bacterial Agents - pharmacology
Antibiotics
Antiinfectives and antibacterials
Bacteria
bimetallic nanoparticles
Bimetals
Communications
Escherichia coli - drug effects
gold
Gold - chemistry
Membranes
Metal Nanoparticles
Nanoparticles
platinum
Platinum - chemistry
Transformations
Tuning
gold
platinum
bimetallic nanoparticles
bacteria
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Summary:We show that bimetallic nanoparticles (NPs) of AuPt without any surface modification are potent antibiotic reagents, while pure Au NPs or pure Pt NPs display no antibiotic activities. The most potent antibacterial AuPt NPs happen to be the most effective catalysts for chemical transformations. The mechanism of antibiotic action includes the dissipation of membrane potential and the elevation of adenosine triphosphate (ATP) levels. These bimetallic NPs are unique in that they do not produce reactive oxygen species as most antibiotics do. Being non‐toxic to human cells, these bimetallic noble NPs might open an entry to a new class of antibiotics. No side‐effect: Bimetallic nanoparticles of AuPt are potent antibiotic reagents with low cytotoxicity. The antibiotic mechanism includes the rupture in the bacterial inner membrane and the increase of intracellular adenosine triphosphate levels, but does not involve the generation of reactive oxygen species (see picture).
Bibliography:ArticleID:ANIE201401035
We acknowledge the Ministry of Science and Technology (2012AA022703, 2012AA030308, 2011CB933201), the Chinese Academy of Science (NNCAS-2010-5, XDA09030305), the National Science Foundation of China (21025520, 91213305, 21222502, 81361140345, 51373043), the Beijing Natural Science Foundation (2122058), and the Beijing Municipal Science and Technology Commission (Z131100002713024) for the funding support.
Funded Access
Ministry of Science and Technology - No. 2012AA022703; No. 2012AA030308; No. 2011CB933201
istex:1411B45F8C66821CFA9A52793A6DF67D79C4E2D0
National Science Foundation - No. 21025520; No. 91213305; No. 21222502; No. 81361140345; No. 51373043
Chinese Academy of Science - No. NNCAS-2010-5; No. XDA09030305
Beijing Municipal Science and Technology Commission - No. Z131100002713024
ark:/67375/WNG-9TH106BH-8
Beijing Natural Science Foundation - No. 2122058
These authors contributed equally to this work.
We acknowledge the Ministry of Science and Technology (2012AA022703, 2012AA030308, 2011CB933201), the Chinese Academy of Science (NNCAS‐2010‐5, XDA09030305), the National Science Foundation of China (21025520, 91213305, 21222502, 81361140345, 51373043), the Beijing Natural Science Foundation (2122058), and the Beijing Municipal Science and Technology Commission (Z131100002713024) for the funding support.
ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
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ISSN:1433-7851
1521-3773
DOI:10.1002/anie.201401035