Tissue plasminogen activator in central nervous system physiology and pathology

Although conventionally associated with fibrin clot degradation, recent work has uncovered new functions for the tissue plasminogen activator (tPA)/plasminogen cascade in central nervous system physiology and pathology. This extracellular proteolytic cascade has been shown to have roles in learning...

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Bibliographic Details
Published inThrombosis and haemostasis Vol. 93; no. 4; p. 655
Main Authors Melchor, Jerry P, Strickland, Sidney
Format Journal Article
LanguageEnglish
Published Germany 01.04.2005
Subjects
Animals
Brain - pathology
Brain - physiology
Gene Expression Regulation - physiology
Humans
Mice
Neurons - pathology
Neurons - physiology
Synapses - physiology
Tissue Plasminogen Activator - genetics
Tissue Plasminogen Activator - physiology
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Summary:Although conventionally associated with fibrin clot degradation, recent work has uncovered new functions for the tissue plasminogen activator (tPA)/plasminogen cascade in central nervous system physiology and pathology. This extracellular proteolytic cascade has been shown to have roles in learning and memory, stress, neuronal degeneration, addiction and Alzheimer's disease. The current review considers the different ways tPA functions in the brain.
ISSN:0340-6245
DOI:10.1160/TH04-12-0838