Idiopathic Interstitial Pneumonia as a Possible Cause of Antineutrophil Cytoplasmic Antibody-Associated Vasculitis: A Case Report

There are conflicting data to date on the causal relationship between idiopathic interstitial pneumonia and antineutrophil cytoplasmic antibody (ANCA): (1) myeloperoxidase-ANCA may play a pathogenetic role in pulmonary fibrosis, or (2) pulmonary fibrosis may induce production of the antibody. In thi...

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Bibliographic Details
Published inArchives of rheumatology Vol. 33; no. 1; pp. 89 - 92
Main Authors Oiwa, Hiroshi, Ooi, Katsuhiro, Oyama, Tetsu, Sugyama, Eiji
Format Journal Article
LanguageEnglish
Published Turkey Turkish League Against Rheumatism 01.03.2018
Prof Sebnem Ataman, President Turkish League Against Rheumatism
Subjects
Antibodies
Antigens
Authorship
Bacterial pneumonia
Blood
Development and progression
Family medical history
Immunoglobulins
Laboratories
Lung diseases
Neutrophils
Patients
Pneumonia
Proteins
Pulmonary fibrosis
Tomography
Urine
Vasculitis
Viral antibodies
Japan
Antineutrophil cytoplasmic antibody; idiopathic interstitial pneumonia; microscopic polyangiitis; vasculitis
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Summary:There are conflicting data to date on the causal relationship between idiopathic interstitial pneumonia and antineutrophil cytoplasmic antibody (ANCA): (1) myeloperoxidase-ANCA may play a pathogenetic role in pulmonary fibrosis, or (2) pulmonary fibrosis may induce production of the antibody. In this article, we describe a case of an elderly female patient with microscopic polyangiitis that developed after positive conversion of myeloperoxidase-ANCA during the course of idiopathic interstitial pneumonia. Our experience as well as similar case reports may suggest that idiopathic interstitial pneumonia may induce production of ANCAs and even ANCA-associated vasculitis.
ISSN:2148-5046
1309-0291
2618-6500
1309-0283
DOI:10.5606/archrheumatol.2018.6532