Prenatal Diagnosis of Atrioventricular Block and QT Interval Prolongation by Fetal Magnetocardiography in a Fetus with Trisomy 18 and SCN5A R1193Q Variant

We report a case of fetal trisomy 18 with SCN5A R1193Q variant that presented with sinus bradycardia, 2 : 1 atrioventricular block (AVB), and QT interval prolongation. These complex arrhythmias were diagnosed by fetal magnetocardiography combined with ultrasound findings. Advanced AVB and ventricula...

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Published inCase Reports in Pediatrics Vol. 2017; no. 2017; pp. 1 - 3
Main Authors Horigome, H., Obata, Mana, Nozaki, Yoshihiro, Kato, Yoshiaki, Takahashi-Igari, Miho, Lin, Lisheng, Hamada, Hiromi
Format Journal Article
LanguageEnglish
Published Cairo, Egypt Hindawi Publishing Corporation 01.01.2017
Hindawi
John Wiley & Sons, Inc
Wiley
Subjects
Arrhythmia
Case Report
Case studies
Diagnosis
Edwards' syndrome
Heart block
Methods
Prenatal diagnosis
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ISSN2090-6803
2090-6811
DOI10.1155/2017/6570465

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Summary:We report a case of fetal trisomy 18 with SCN5A R1193Q variant that presented with sinus bradycardia, 2 : 1 atrioventricular block (AVB), and QT interval prolongation. These complex arrhythmias were diagnosed by fetal magnetocardiography combined with ultrasound findings. Advanced AVB and ventricular arrhythmias were confirmed after birth. Genetic testing of the baby revealed a SCN5A R1193Q variant, which we considered could account for the various arrhythmias in this case.
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Academic Editor: Seyed Mohsen Dehghani
ISSN:2090-6803
2090-6811
DOI:10.1155/2017/6570465