PYRROXAMYCIN, A NEW ANTIBIOTIC TAXONOMY, FERMENTATION, ISOLATION, STRUCTURE DETERMINATION AND BIOLOGICAL PROPERTIES

• Published in: Journal of antibiotics Vol. 40; no. 7; pp. 961 - 969
• Main Authors: YANO, KENICHI, OONO, JUNJI, MOGI, KINICHI, ASAOKA, TAKEMITSU, NAKASHIMA, TOSHIAKI
• Format: Journal Article
• Language: English
• Published: Tokyo JAPAN ANTIBIOTICS RESEARCH ASSOCIATION 1987; Japan Antibiotics Research Association
• Subjects: 4,5-dichloro-2-(6',8'-dichloro-4'H-1',3'-benzodioxin-4'-yl)-3-nit r opyrrole; Anti-Bacterial Agents - isolation & purification; Anti-Bacterial Agents - metabolism; Antibacterial agents; Antibiotics; Antibiotics. Antiinfectious agents. Antiparasitic agents; Biological and medical sciences; Biotechnology; Chemical Phenomena; Chemistry, Physical; Fermentation; Fundamental and applied biological sciences. Psychology; gram-positive bacteria; Health. Pharmaceutical industry; Industrial applications and implications. Economical aspects; Magnetic Resonance Spectroscopy; Medical sciences; Pharmacology. Drug treatments; Production of active biomolecules; Pyrroles - isolation & purification; Pyrroles - metabolism; pyrroxamycin; Spectrophotometry, Infrared; Streptomyces; Streptomyces - analysis; Streptomycetaceae; Molecular structure; Taxonomy; Streptomyces; Fermentation; Biological activity; Actinomycetales; Antibiotic; Antifungal agent; Production; Bacteria; Isolation; Actinomycetes; Antibacterial agent; Physicochemical properties
• ISSN: 0021-8820; 1881-1469
• DOI: 10.7164/antibiotics.40.961

A strain of streptomycete was found to produce a new antibiotic pyrroxamycin. This compound was isolated from the culture broth of Streptomyces sp. S46506. The chemical structure was determined to be 4, 5-dichloro-2-(6', 8'-dichloro-4'H-1', 3'-benzodioxin-4'-yl)-3-nitropyrrole by its chemical character and 1H and 13C NMR spectral analysis. Pyrroxamycin was active against Gram-positive bacteria and dermatophytes.