Recombinant vesicular stomatitis virus–vectored vaccine induces long-lasting immunity against Nipah virus disease

• Published in: The Journal of clinical investigation Vol. 133; no. 3; pp. 1 - 15
• Main Authors: Woolsey, Courtney, Borisevich, Viktoriya, Fears, Alyssa C., Agans, Krystle N., Deer, Daniel J., Prasad, Abhishek N., O’Toole, Rachel, Foster, Stephanie L., Dobias, Natalie S., Geisbert, Joan B., Fenton, Karla A., Cross, Robert W., Geisbert, Thomas W.
• Format: Journal Article
• Language: English
• Published: United States American Society for Clinical Investigation 01.02.2023
• Subjects: Adenoviruses; Animals; Antibodies, Viral; Biomedical research; Chlorocebus aethiops; COVID-19; Ebola virus; Encephalitis; Epidemics; Genetic aspects; Genetic vectors; Glycoproteins; Humans; Immunity; Immunity (Disease); Immunological research; Infectious disease; Lethal dose; Lethality; Licenses; Nipah virus; Nipah Virus - genetics; Pandemics; Pathogens; Respiratory diseases; Stomatitis; Transcriptomics; Vaccines; Vesicular Stomatitis; Vesiculovirus - genetics; Viral vaccines; Viral Vaccines - genetics; Viruses; United States; Bangladesh; Malaysia; United States > US; India; Infectious disease; Adaptive immunity; Vaccines

The emergence of the novel henipavirus, Langya virus, received global attention after the virus sickened over three dozen people in China. There is heightened concern that henipaviruses, as respiratory pathogens, could spark another pandemic, most notably the deadly Nipah virus (NiV). NiV causes nea...