What real influence does the proto-oncogene c-myc have in OSCC behavior?

The influence of c-myc in the carcinogenic process has been previously described although in the specific case of oral tumors it has been poorly tested. Myc proteins are a family of proto-oncogenes involved in the cell proliferation regulation, differentiation and apoptosis. The goal of this paper i...

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Published inOral oncology Vol. 47; no. 8; pp. 688 - 692
Main Authors Pérez-Sayáns, Mario, Suárez-Peñaranda, José Manuel, Pilar, Gayoso-Diz, Barros-Angueira, Francisco, Gándara-Rey, José Manuel, García-García, Abel
Format Journal Article
LanguageEnglish
Published Kidlington Elsevier Ltd 01.08.2011
Elsevier
Subjects
Biological and medical sciences
C-myc
Carcinoma, Squamous Cell - genetics
Carcinoma, Squamous Cell - metabolism
Gene Amplification
Gene Expression Regulation, Neoplastic
Genetic amplification
Hematology, Oncology and Palliative Medicine
Humans
Medical sciences
Mouth Neoplasms - genetics
Mouth Neoplasms - metabolism
Oncogene
Oncogenes - physiology
Oral squamous cell carcinoma (OSCC)
Otolaryngology
Otorhinolaryngology. Stomatology
Proto-Oncogene Proteins c-myc - genetics
Proto-Oncogene Proteins c-myc - metabolism
Tumors
Upper respiratory tract, upper alimentary tract, paranasal sinuses, salivary glands: diseases, semeiology
Oral squamous cell carcinoma (OSCC)
C-myc
Oncogene
Genetic amplification
Stomatology
ENT
Malignant tumor
Oral squamous cell carcinoma
Amplification
Cancerology
C-Onc gene
Genetics
Oral cavity disease
Behavior
Onc gene
Protooncogene
Cancer
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Abstract The influence of c-myc in the carcinogenic process has been previously described although in the specific case of oral tumors it has been poorly tested. Myc proteins are a family of proto-oncogenes involved in the cell proliferation regulation, differentiation and apoptosis. The goal of this paper is to describe the functions of c-myc and its role as oncogene, assessing its expression by immunohistochemistry and genetic amplification studies, and studying its relationship with tumoral clinical and pathological variables, and describing genetic and molecular interactions in OSCC.
AbstractList Abstract The influence of c-myc in the carcinogenic process has been previously described although in the specific case of oral tumors it has been poorly tested. Myc proteins are a family of proto-oncogenes involved in the cell proliferation regulation, differentiation and apoptosis. The goal of this paper is to describe the functions of c-myc and its role as oncogene, assessing its expression by immunohistochemistry and genetic amplification studies, and studying its relationship with tumoral clinical and pathological variables, and describing genetic and molecular interactions in OSCC.
The influence of c-myc in the carcinogenic process has been previously described although in the specific case of oral tumors it has been poorly tested. Myc proteins are a family of proto-oncogenes involved in the cell proliferation regulation, differentiation and apoptosis. The goal of this paper is to describe the functions of c-myc and its role as oncogene, assessing its expression by immunohistochemistry and genetic amplification studies, and studying its relationship with tumoral clinical and pathological variables, and describing genetic and molecular interactions in OSCC.The influence of c-myc in the carcinogenic process has been previously described although in the specific case of oral tumors it has been poorly tested. Myc proteins are a family of proto-oncogenes involved in the cell proliferation regulation, differentiation and apoptosis. The goal of this paper is to describe the functions of c-myc and its role as oncogene, assessing its expression by immunohistochemistry and genetic amplification studies, and studying its relationship with tumoral clinical and pathological variables, and describing genetic and molecular interactions in OSCC.
The influence of c-myc in the carcinogenic process has been previously described although in the specific case of oral tumors it has been poorly tested. Myc proteins are a family of proto-oncogenes involved in the cell proliferation regulation, differentiation and apoptosis. The goal of this paper is to describe the functions of c-myc and its role as oncogene, assessing its expression by immunohistochemistry and genetic amplification studies, and studying its relationship with tumoral clinical and pathological variables, and describing genetic and molecular interactions in OSCC.
Author Gándara-Rey, José Manuel
Barros-Angueira, Francisco
García-García, Abel
Pilar, Gayoso-Diz
Pérez-Sayáns, Mario
Suárez-Peñaranda, José Manuel
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  surname: García-García
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  email: abel.garcia@usc.es
  organization: Oral Medicine, Oral Surgery and Implantology Unit, Faculty of Medicine and Dentistry, Instituto de Investigación Sanitaria de Santiago (IDIS), Santiago de Compostela, Spain
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Issue 8
Keywords Oral squamous cell carcinoma (OSCC)
C-myc
Oncogene
Genetic amplification
Stomatology
ENT
Malignant tumor
Oral squamous cell carcinoma
Amplification
Cancerology
C-Onc gene
Genetics
Oral cavity disease
Behavior
Onc gene
Protooncogene
Cancer
Language English
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CC BY 4.0
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Snippet The influence of c-myc in the carcinogenic process has been previously described although in the specific case of oral tumors it has been poorly tested. Myc...
Abstract The influence of c-myc in the carcinogenic process has been previously described although in the specific case of oral tumors it has been poorly...
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SubjectTerms Biological and medical sciences
C-myc
Carcinoma, Squamous Cell - genetics
Carcinoma, Squamous Cell - metabolism
Gene Amplification
Gene Expression Regulation, Neoplastic
Genetic amplification
Hematology, Oncology and Palliative Medicine
Humans
Medical sciences
Mouth Neoplasms - genetics
Mouth Neoplasms - metabolism
Oncogene
Oncogenes - physiology
Oral squamous cell carcinoma (OSCC)
Otolaryngology
Otorhinolaryngology. Stomatology
Proto-Oncogene Proteins c-myc - genetics
Proto-Oncogene Proteins c-myc - metabolism
Tumors
Upper respiratory tract, upper alimentary tract, paranasal sinuses, salivary glands: diseases, semeiology
Title What real influence does the proto-oncogene c-myc have in OSCC behavior?
URI https://www.clinicalkey.com/#!/content/1-s2.0-S136883751100193X
https://www.clinicalkey.es/playcontent/1-s2.0-S136883751100193X
https://dx.doi.org/10.1016/j.oraloncology.2011.05.016
https://www.ncbi.nlm.nih.gov/pubmed/21708481
https://www.proquest.com/docview/878822880
https://www.proquest.com/docview/907169293
Volume 47
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