What real influence does the proto-oncogene c-myc have in OSCC behavior?

• Published in: Oral oncology Vol. 47; no. 8; pp. 688 - 692
• Main Authors: Pérez-Sayáns, Mario, Suárez-Peñaranda, José Manuel, Pilar, Gayoso-Diz, Barros-Angueira, Francisco, Gándara-Rey, José Manuel, García-García, Abel
• Format: Journal Article
• Language: English
• Published: Kidlington Elsevier Ltd 01.08.2011; Elsevier
• Subjects: Biological and medical sciences; C-myc; Carcinoma, Squamous Cell - genetics; Carcinoma, Squamous Cell - metabolism; Gene Amplification; Gene Expression Regulation, Neoplastic; Genetic amplification; Hematology, Oncology and Palliative Medicine; Humans; Medical sciences; Mouth Neoplasms - genetics; Mouth Neoplasms - metabolism; Oncogene; Oncogenes - physiology; Oral squamous cell carcinoma (OSCC); Otolaryngology; Otorhinolaryngology. Stomatology; Proto-Oncogene Proteins c-myc - genetics; Proto-Oncogene Proteins c-myc - metabolism; Tumors; Upper respiratory tract, upper alimentary tract, paranasal sinuses, salivary glands: diseases, semeiology; Oral squamous cell carcinoma (OSCC); C-myc; Oncogene; Genetic amplification; Stomatology; ENT; Malignant tumor; Oral squamous cell carcinoma; Amplification; Cancerology; C-Onc gene; Genetics; Oral cavity disease; Behavior; Onc gene; Protooncogene; Cancer
• ISSN: 1368-8375; 1879-0593; 1879-0593
• DOI: 10.1016/j.oraloncology.2011.05.016

The influence of c-myc in the carcinogenic process has been previously described although in the specific case of oral tumors it has been poorly tested. Myc proteins are a family of proto-oncogenes involved in the cell proliferation regulation, differentiation and apoptosis. The goal of this paper is to describe the functions of c-myc and its role as oncogene, assessing its expression by immunohistochemistry and genetic amplification studies, and studying its relationship with tumoral clinical and pathological variables, and describing genetic and molecular interactions in OSCC.