Biology and evolution of poorly differentiated neuroendocrine tumors
Rubin and colleagues discuss the origin and evolution of poorly differentiated neuroendocrine tumors, and highlight potential new therapeutic strategies. Neuroendocrine (NE) cancers are a diverse group of neoplasms typically diagnosed and treated on the basis of their site of origin. This Perspectiv...
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Published in | Nature medicine Vol. 23; no. 6; pp. 664 - 673 |
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Main Authors | , , , |
Format | Journal Article |
Language | English |
Published |
New York
Nature Publishing Group US
01.06.2017
Nature Publishing Group |
Subjects | |
Online Access | Get full text |
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Summary: | Rubin and colleagues discuss the origin and evolution of poorly differentiated neuroendocrine tumors, and highlight potential new therapeutic strategies.
Neuroendocrine (NE) cancers are a diverse group of neoplasms typically diagnosed and treated on the basis of their site of origin. This Perspective focuses on advances in our understanding of the tumorigenesis and treatment of poorly differentiated neuroendocrine tumors. Recent evidence from sequencing indicates that, although neuroendocrine tumors can arise
de novo
, they can also develop as a result of lineage plasticity in response to pressure from targeted therapies. We discuss the shared genomic alterations of these tumors independently of their site of origin, and we explore potential therapeutic strategies on the basis of recent biological findings. |
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Bibliography: | ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 |
ISSN: | 1078-8956 1546-170X |
DOI: | 10.1038/nm.4341 |