Regulation of muscle stem cell fate

• Published in: Cell regeneration Vol. 11; no. 1; pp. 40 - 13
• Main Authors: Fu, Xin, Zhuang, Cheng-le, Hu, Ping
• Format: Journal Article
• Language: English
• Published: Singapore Springer Nature Singapore 02.12.2022; Springer Nature B.V; SpringerOpen
• Subjects: Asymmetric division; Biomedical and Life Sciences; Biomedicine; Cell Biology; Cell cycle; Cell differentiation; Cell fate; Cell self-renewal; Epigenetics; Extracellular matrix; Gene expression; Life Sciences; Metabolism; Metabolites; Microenvironments; MuSC heterogeneity; Muscle stem cells; Musculoskeletal system; Proteins; Regenerative medicine; Review; Senescence; Skeletal muscle; Skeletal Muscle Regeneration; Stem Cells; Transcription factors; Transcription regulation; Asymmetric division; Skeletal muscle regeneration; MuSC heterogeneity; Microenvironments; Muscle stem cells; Transcription regulation
• ISSN: 2045-9769; 2045-9769
• DOI: 10.1186/s13619-022-00142-7

Skeletal muscle plays a critical role in human health. Muscle stem cells (MuSCs) serve as the major cell type contributing to muscle regeneration by directly differentiating to mature muscle cells. MuSCs usually remain quiescent with occasionally self-renewal and are activated to enter cell cycle for proliferation followed by differentiation upon muscle injury or under pathological conditions. The quiescence maintenance, activation, proliferation, and differentiation of MuSCs are tightly regulated. The MuSC cell-intrinsic regulatory network and the microenvironments work coordinately to orchestrate the fate transition of MuSCs. The heterogeneity of MuSCs further complicates the regulation of MuSCs. This review briefly summarizes the current progress on the heterogeneity of MuSCs and the microenvironments, epigenetic, and transcription regulations of MuSCs.