Probiotics mitigating subclinical necrotic enteritis (SNE) as potential alternatives to antibiotics in poultry

• Published in: AMB Express Vol. 10; no. 1; p. 50
• Main Authors: Khalique, Abdul, Zeng, Dong, Shoaib, Muhammad, Wang, Hesong, Qing, Xiaodan, Rajput, Danish Sharafat, Pan, Kangcheng, Ni, Xueqin
• Format: Journal Article
• Language: English
• Published: Berlin/Heidelberg Springer Berlin Heidelberg 14.03.2020; Springer Nature B.V; SpringerOpen
• Subjects: Alternatives; Antibiotics; Antiinfectives and antibacterials; Antimicrobial growth promoters; Bacillus; Biomedical and Life Sciences; Biotechnology; Clostridium perfringens; Economic impact; Enteritis; Essential oils; Growth promoters; Intestine; Lactic acid; Lactic acid bacteria; Life Sciences; Metabolites; Microbial Genetics and Genomics; Microbiology; Microorganisms; Mini-Review; Molecular modelling; Mucosa; Nutrients; Organic acids; Phages; Poultry; Probiotics; Promoters; Secondary metabolites; Subclinical necrotic enteritis; Probiotics; Subclinical necrotic enteritis; Antimicrobial growth promoters; Lactic acid bacteria; Clostridium perfringens; Bacillus
• ISSN: 2191-0855; 2191-0855
• DOI: 10.1186/s13568-020-00989-6

Subclinical necrotic enteritis (SNE) caused by Clostridium perfringens ( CP ), is an important disease in chickens, which causes huge economic losses by damaging the intestinal mucosa, decreasing digestion and absorption of nutrients. Use of antibiotics at a sub-therapeutic level as antimicrobial growth promoters in poultry feed prevents the birds from SNE and improves growth. Due to the ban on the use of antibiotics in 2006 as antimicrobial growth promoters have led to the reemergence of the disease. Worldwide numerous studies have been carried out to investigate the alternatives to antibiotics for the prevention of SNE. Possible alternatives to control SNE include probiotics, prebiotics, bacteriophages, essential oils, organic acids, secondary metabolites and other microbial products. Currently, probiotics are most extensively used in poultry production as an alternative to antibiotics. This review summarizes recent insights and experimental evidence on the use of different microorganisms like Bacillus, Lactic acid bacteria, Bifidobacteria, Enterococcus, yeast , etc. as valuable probiotics for prevention of SNE and potential molecular mechanisms responsible for ameliorating effects of probiotics against SNE.