APT‐weighted MRI: Techniques, current neuro applications, and challenging issues

Amide proton transfer‐weighted (APTw) imaging is a molecular MRI technique that generates image contrast based predominantly on the amide protons in mobile cellular proteins and peptides that are endogenous in tissue. This technique, the most studied type of chemical exchange saturation transfer ima...

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Bibliographic Details
Published inJournal of magnetic resonance imaging Vol. 50; no. 2; pp. 347 - 364
Main Authors Zhou, Jinyuan, Heo, Hye‐Young, Knutsson, Linda, van Zijl, Peter C.M., Jiang, Shanshan
Format Journal Article
LanguageEnglish
Published Hoboken, USA John Wiley & Sons, Inc 01.08.2019
Wiley Subscription Services, Inc
Subjects
Alzheimer's disease
Annan fysik
APT‐weighted imaging
Brain
Brain cancer
brain tumor
Brain tumors
CEST imaging
Clinical Medicine
Dependence
Fysik
Head injuries
Image contrast
Klinisk medicin
Magnetic resonance imaging
Medical and Health Sciences
Medical imaging
Medicin och hälsovetenskap
molecular imaging
Movement disorders
Multiple sclerosis
Natural Sciences
Naturvetenskap
Neurodegenerative diseases
Neuroimaging
Organic chemistry
Other Physics Topics
Parkinson's disease
Peptides
pH effects
Physical Sciences
Proteins
Protons
Radiologi och bildbehandling
Radiology and Medical Imaging
Radiology, Nuclear Medicine and Medical Imaging
stroke
Traumatic brain injury
Tumors
CEST imaging
brain tumor
APT-weighted imaging
molecular imaging
stroke
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Abstract Amide proton transfer‐weighted (APTw) imaging is a molecular MRI technique that generates image contrast based predominantly on the amide protons in mobile cellular proteins and peptides that are endogenous in tissue. This technique, the most studied type of chemical exchange saturation transfer imaging, has been used successfully for imaging of protein content and pH, the latter being possible due to the strong dependence of the amide proton exchange rate on pH. In this article we briefly review the basic principles and recent technical advances of APTw imaging, which is showing promise clinically, especially for characterizing brain tumors and distinguishing recurrent tumor from treatment effects. Early applications of this approach to stroke, Alzheimer's disease, Parkinson's disease, multiple sclerosis, and traumatic brain injury are also illustrated. Finally, we outline the technical challenges for clinical APT‐based imaging and discuss several controversies regarding the origin of APTw imaging signals in vivo. Level of Evidence: 3 Technical Efficacy Stage: 3 J. Magn. Reson. Imaging 2019;50:347–364.
AbstractList Amide proton transfer‐weighted (APTw) imaging is a molecular MRI technique that generates image contrast based predominantly on the amide protons in mobile cellular proteins and peptides that are endogenous in tissue. This technique, the most studied type of chemical exchange saturation transfer imaging, has been used successfully for imaging of protein content and pH, the latter being possible due to the strong dependence of the amide proton exchange rate on pH. In this article we briefly review the basic principles and recent technical advances of APTw imaging, which is showing promise clinically, especially for characterizing brain tumors and distinguishing recurrent tumor from treatment effects. Early applications of this approach to stroke, Alzheimer's disease, Parkinson's disease, multiple sclerosis, and traumatic brain injury are also illustrated. Finally, we outline the technical challenges for clinical APT‐based imaging and discuss several controversies regarding the origin of APTw imaging signals in vivo. Level of Evidence: 3 Technical Efficacy Stage: 3 J. Magn. Reson. Imaging 2019;50:347–364.
Amide proton transfer-weighted (APTw) imaging is a molecular MRI technique that generates image contrast based predominantly on the amide protons in mobile cellular proteins and peptides that are endogenous in tissue. This technique, the most studied type of chemical exchange saturation transfer (CEST) imaging, has been used successfully for imaging of protein content and pH, the latter being possible due to the strong dependence of the amide proton exchange rate on pH. In this paper, we briefly review the basic principles and recent technical advances of APTw imaging, which is showing promise clinically, especially for characterizing brain tumors and distinguishing recurrent tumor from treatment effects. Early applications of this approach to stroke, Alzheimer’s disease, Parkinson’s disease, multiple sclerosis, and traumatic brain injury are also illustrated. Finally, we will outline technical challenges for clinical APT-based imaging and discuss several controversies regarding the origin of APTw imaging signals in vivo.
Amide proton transfer‐weighted (APTw) imaging is a molecular MRI technique that generates image contrast based predominantly on the amide protons in mobile cellular proteins and peptides that are endogenous in tissue. This technique, the most studied type of chemical exchange saturation transfer imaging, has been used successfully for imaging of protein content and pH, the latter being possible due to the strong dependence of the amide proton exchange rate on pH. In this article we briefly review the basic principles and recent technical advances of APTw imaging, which is showing promise clinically, especially for characterizing brain tumors and distinguishing recurrent tumor from treatment effects. Early applications of this approach to stroke, Alzheimer's disease, Parkinson's disease, multiple sclerosis, and traumatic brain injury are also illustrated. Finally, we outline the technical challenges for clinical APT‐based imaging and discuss several controversies regarding the origin of APTw imaging signals invivo.
Amide proton transfer-weighted (APTw) imaging is a molecular MRI technique that generates image contrast based predominantly on the amide protons in mobile cellular proteins and peptides that are endogenous in tissue. This technique, the most studied type of chemical exchange saturation transfer imaging, has been used successfully for imaging of protein content and pH, the latter being possible due to the strong dependence of the amide proton exchange rate on pH. In this article we briefly review the basic principles and recent technical advances of APTw imaging, which is showing promise clinically, especially for characterizing brain tumors and distinguishing recurrent tumor from treatment effects. Early applications of this approach to stroke, Alzheimer's disease, Parkinson's disease, multiple sclerosis, and traumatic brain injury are also illustrated. Finally, we outline the technical challenges for clinical APT-based imaging and discuss several controversies regarding the origin of APTw imaging signals in vivo. Level of Evidence: 3 Technical Efficacy Stage: 3 J. Magn. Reson. Imaging 2019;50:347-364.
Amide proton transfer‐weighted (APTw) imaging is a molecular MRI technique that generates image contrast based predominantly on the amide protons in mobile cellular proteins and peptides that are endogenous in tissue. This technique, the most studied type of chemical exchange saturation transfer imaging, has been used successfully for imaging of protein content and pH, the latter being possible due to the strong dependence of the amide proton exchange rate on pH. In this article we briefly review the basic principles and recent technical advances of APTw imaging, which is showing promise clinically, especially for characterizing brain tumors and distinguishing recurrent tumor from treatment effects. Early applications of this approach to stroke, Alzheimer's disease, Parkinson's disease, multiple sclerosis, and traumatic brain injury are also illustrated. Finally, we outline the technical challenges for clinical APT‐based imaging and discuss several controversies regarding the origin of APTw imaging signals in vivo.
Amide proton transfer‐weighted (APTw) imaging is a molecular MRI technique that generates image contrast based predominantly on the amide protons in mobile cellular proteins and peptides that are endogenous in tissue. This technique, the most studied type of chemical exchange saturation transfer imaging, has been used successfully for imaging of protein content and pH, the latter being possible due to the strong dependence of the amide proton exchange rate on pH. In this article we briefly review the basic principles and recent technical advances of APTw imaging, which is showing promise clinically, especially for characterizing brain tumors and distinguishing recurrent tumor from treatment effects. Early applications of this approach to stroke, Alzheimer's disease, Parkinson's disease, multiple sclerosis, and traumatic brain injury are also illustrated. Finally, we outline the technical challenges for clinical APT‐based imaging and discuss several controversies regarding the origin of APTw imaging signals in vivo.Level of Evidence: 3Technical Efficacy Stage: 3J. Magn. Reson. Imaging 2019;50:347–364.
Amide proton transfer-weighted (APTw) imaging is a molecular MRI technique that generates image contrast based predominantly on the amide protons in mobile cellular proteins and peptides that are endogenous in tissue. This technique, the most studied type of chemical exchange saturation transfer imaging, has been used successfully for imaging of protein content and pH, the latter being possible due to the strong dependence of the amide proton exchange rate on pH. In this article we briefly review the basic principles and recent technical advances of APTw imaging, which is showing promise clinically, especially for characterizing brain tumors and distinguishing recurrent tumor from treatment effects. Early applications of this approach to stroke, Alzheimer's disease, Parkinson's disease, multiple sclerosis, and traumatic brain injury are also illustrated. Finally, we outline the technical challenges for clinical APT-based imaging and discuss several controversies regarding the origin of APTw imaging signals in vivo. Level of Evidence: 3 Technical Efficacy Stage: 3 J. Magn. Reson. Imaging 2019;50:347-364.Amide proton transfer-weighted (APTw) imaging is a molecular MRI technique that generates image contrast based predominantly on the amide protons in mobile cellular proteins and peptides that are endogenous in tissue. This technique, the most studied type of chemical exchange saturation transfer imaging, has been used successfully for imaging of protein content and pH, the latter being possible due to the strong dependence of the amide proton exchange rate on pH. In this article we briefly review the basic principles and recent technical advances of APTw imaging, which is showing promise clinically, especially for characterizing brain tumors and distinguishing recurrent tumor from treatment effects. Early applications of this approach to stroke, Alzheimer's disease, Parkinson's disease, multiple sclerosis, and traumatic brain injury are also illustrated. Finally, we outline the technical challenges for clinical APT-based imaging and discuss several controversies regarding the origin of APTw imaging signals in vivo. Level of Evidence: 3 Technical Efficacy Stage: 3 J. Magn. Reson. Imaging 2019;50:347-364.
Author Jiang, Shanshan
Heo, Hye‐Young
Knutsson, Linda
van Zijl, Peter C.M.
Zhou, Jinyuan
AuthorAffiliation 1 Division of MR Research, Department of Radiology, Johns Hopkins University, Baltimore, Maryland, USA
2 F.M. Kirby Research Center for Functional Brain Imaging, Kennedy Krieger Institute, Baltimore, Maryland, USA
3 Department of Medical Radiation Physics, Lund University, Lund, Sweden
AuthorAffiliation_xml – name: 1 Division of MR Research, Department of Radiology, Johns Hopkins University, Baltimore, Maryland, USA
– name: 2 F.M. Kirby Research Center for Functional Brain Imaging, Kennedy Krieger Institute, Baltimore, Maryland, USA
– name: 3 Department of Medical Radiation Physics, Lund University, Lund, Sweden
Author_xml – sequence: 1
  givenname: Jinyuan
  surname: Zhou
  fullname: Zhou, Jinyuan
  email: jzhou2@jhmi.edu
  organization: Kennedy Krieger Institute
– sequence: 2
  givenname: Hye‐Young
  surname: Heo
  fullname: Heo, Hye‐Young
  organization: Kennedy Krieger Institute
– sequence: 3
  givenname: Linda
  surname: Knutsson
  fullname: Knutsson, Linda
  organization: Lund University
– sequence: 4
  givenname: Peter C.M.
  surname: van Zijl
  fullname: van Zijl, Peter C.M.
  organization: Kennedy Krieger Institute
– sequence: 5
  givenname: Shanshan
  surname: Jiang
  fullname: Jiang, Shanshan
  organization: Kennedy Krieger Institute
BackLink https://www.ncbi.nlm.nih.gov/pubmed/30663162$$D View this record in MEDLINE/PubMed
https://lup.lub.lu.se/record/35d06584-f4d1-454b-9e76-53ca6bbc5577$$DView record from Swedish Publication Index
oai:portal.research.lu.se:publications/35d06584-f4d1-454b-9e76-53ca6bbc5577$$DView record from Swedish Publication Index
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brain tumor
APT-weighted imaging
molecular imaging
stroke
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Snippet Amide proton transfer‐weighted (APTw) imaging is a molecular MRI technique that generates image contrast based predominantly on the amide protons in mobile...
Amide proton transfer-weighted (APTw) imaging is a molecular MRI technique that generates image contrast based predominantly on the amide protons in mobile...
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SubjectTerms Alzheimer's disease
Annan fysik
APT‐weighted imaging
Brain
Brain cancer
brain tumor
Brain tumors
CEST imaging
Clinical Medicine
Dependence
Fysik
Head injuries
Image contrast
Klinisk medicin
Magnetic resonance imaging
Medical and Health Sciences
Medical imaging
Medicin och hälsovetenskap
molecular imaging
Movement disorders
Multiple sclerosis
Natural Sciences
Naturvetenskap
Neurodegenerative diseases
Neuroimaging
Organic chemistry
Other Physics Topics
Parkinson's disease
Peptides
pH effects
Physical Sciences
Proteins
Protons
Radiologi och bildbehandling
Radiology and Medical Imaging
Radiology, Nuclear Medicine and Medical Imaging
stroke
Traumatic brain injury
Tumors
Title APT‐weighted MRI: Techniques, current neuro applications, and challenging issues
URI https://onlinelibrary.wiley.com/doi/abs/10.1002%2Fjmri.26645
https://www.ncbi.nlm.nih.gov/pubmed/30663162
https://www.proquest.com/docview/2256022522
https://www.proquest.com/docview/2179385814
https://pubmed.ncbi.nlm.nih.gov/PMC6625919
https://lup.lub.lu.se/record/35d06584-f4d1-454b-9e76-53ca6bbc5577
oai:portal.research.lu.se:publications/35d06584-f4d1-454b-9e76-53ca6bbc5577
Volume 50
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