Pacemaking function of two simplified cell models

• Published in: PloS one Vol. 17; no. 4; p. e0257935
• Main Authors: Ryzhii, Maxim, Ryzhii, Elena
• Format: Journal Article
• Language: English
• Published: United States Public Library of Science 11.04.2022; Public Library of Science (PLoS)
• Subjects: Action Potentials - physiology; Biological models (mathematics); Biology and Life Sciences; Cell culture; Computational neuroscience; Computer and Information Sciences; Computer Simulation; Dynamical systems; Electrophysiology; Engineering and Technology; Evaluation; Hypothesis testing; Intestine; Ion Channels; Mathematical models; Medical equipment; Medicine and Health Sciences; Modelling; Models, Cardiovascular; Nonlinear analysis; Nonlinear dynamics; Numerical analysis; Numerical simulations; Ordinary differential equations; Organs; Pacemaker, Artificial (Heart); Pacemakers; Physical Sciences; Physiology; Research and Analysis Methods; Simulation; Sinoatrial Node - physiology; Variables; Japan
• ISSN: 1932-6203; 1932-6203
• DOI: 10.1371/journal.pone.0257935

Simplified nonlinear models of biological cells are widely used in computational electrophysiology. The models reproduce qualitatively many of the characteristics of various organs, such as the heart, brain, and intestine. In contrast to complex cellular ion-channel models, the simplified models usually contain a small number of variables and parameters, which facilitates nonlinear analysis and reduces computational load. In this paper, we consider pacemaking variants of the Aliev-Panfilov and Corrado two-variable excitable cell models. We conducted a numerical simulation study of these models and investigated the main nonlinear dynamic features of both isolated cells and 1D coupled pacemaker-excitable systems. Simulations of the 2D sinoatrial node and 3D intestine tissue as application examples of combined pacemaker-excitable systems demonstrated results similar to obtained previously. The uniform formulation for the conventional excitable cell models and proposed pacemaker models allows a convenient and easy implementation for the construction of personalized physiological models, inverse tissue modeling, and development of real-time simulation systems for various organs that contain both pacemaker and excitable cells.