Fluoride-Catalyzed Cross-Coupling of Silylamides to CF 3 -Acrylates: Access to Highly Functionalized Trifluoromethylated and Quaternary Fluorinated Molecular Architectures
A direct and simple catalytic coupling of nonfluorinated and fluorinated silylbutenamides with β-CF α,β-unsaturated esters mediated by fluoride ion was carried out. The transformation proceeded with excellent yields to afford new, highly functionalized trifluoromethylated and quaternary fluorinated...
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| Published in | Organic letters Vol. 26; no. 29; pp. 6130 - 6135 |
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| Main Author | |
| Format | Journal Article |
| Language | English |
| Published |
United States
26.07.2024
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| Online Access | Get full text |
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| Summary: | A direct and simple catalytic coupling of nonfluorinated and fluorinated silylbutenamides with β-CF
α,β-unsaturated esters mediated by fluoride ion was carried out. The transformation proceeded with excellent yields to afford new, highly functionalized trifluoromethylated and quaternary fluorinated products. |
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| ISSN: | 1523-7060 1523-7052 |
| DOI: | 10.1021/acs.orglett.4c01895 |