The relationship between organ-tissue body composition and resting energy expenditure in prepubertal children

• Published in: European journal of clinical nutrition Vol. 73; no. 8; pp. 1149 - 1154
• Main Authors: Midorikawa, Taishi, Hikihara, Yuki, Ohta, Megumi, Ando, Takafumi, Torii, Suguru, Sakamoto, Shizuo, Tanaka, Shigeho
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 01.08.2019; Nature Publishing Group
• Subjects: 692/700/1720; 692/700/2814; 692/700/2817; Absorptiometry, Photon; Adipose tissue; Adipose Tissue - anatomy & histology; Basal Metabolism - physiology; Body composition; Body Composition - physiology; Body mass index; Brain; Brain - anatomy & histology; Calorimetry; Calorimetry, Indirect; Child; Children; Children & youth; Clinical Nutrition; Dual energy X-ray absorptiometry; Energy expenditure; Epidemiology; Female; Girls; Health aspects; Humans; Internal Medicine; Japan; Kidney - anatomy & histology; Liver - anatomy & histology; Magnetic Resonance Imaging; Male; Mathematical analysis; Measurement; Medicine; Medicine & Public Health; Metabolic Diseases; Metabolic rate; Metabolism; Muscle, Skeletal - anatomy & histology; Muscles; Neuroimaging; NMR; Nuclear magnetic resonance; Observations; Organ Size; Organs; Puberty; Public Health; Rate constants; Skeletal muscle; Japan
• ISSN: 0954-3007; 1476-5640
• DOI: 10.1038/s41430-018-0344-2

Background/Objectives In this study, we ascertained the relationship between resting energy expenditure (REE) obtained using two procedures: indirect calorimetry and from organ-tissue mass, calculated employing magnetic resonance imaging (MRI), and adult metabolic rate constants, in prepubertal children. Differences between the measured and the calculated REEs were assessed according to age at puberty approaching stage. Subjects/Methods We recruited 6–12 years old 110 healthy Japanese prepubertal children (40 girls and 70 boys). Organ-tissue masses for different organs (skeletal muscle, liver, kidneys, brain and adipose tissue) were determined using MRI and dual-energy X-ray absorptiometry. Heart and residual masses were calculated on the basis of each equation. REE was measured using the Douglas bag technique (measured REE). On the other hand, calculated REE was obtained by multiplying the sum of body compartments with the corresponding adult tissue respiration rate. Results The measured REE was significantly greater than the calculated REE in both, boys and girls, although a significant association was noticed between the two REEs in both the sexes. Besides, correlation between age and difference in the two REEs was found to be significant only in girls. Conclusions The present study revealed that: (1) measured and calculated REEs differ by approximately 300 kcal/day in a relatively large sample of prepubertal children, and (2) the difference in organ-tissue mass between the measured and calculated REEs increased from approximately 200 to 400 kcal/day during the developmental process in girls but not in boys.