Effect of Beta-Blockade on Mortality among High-Risk and Low-Risk Patients after Myocardial Infarction

Several large trials have demonstrated that the long-term administration of beta-adrenergic blockers to patients after myocardial infarction improves survival. 1 – 3 Although the percentage of such patients receiving beta-blockade has recently increased, physicians still reportedly prescribe beta-bl...

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Bibliographic Details
Published inThe New England journal of medicine Vol. 339; no. 8; pp. 489 - 497
Main Authors Gottlieb, Stephen S, McCarter, Robert J, Vogel, Robert A
Format Journal Article
LanguageEnglish
Published Boston, MA Massachusetts Medical Society 20.08.1998
Subjects
Adrenergic beta-Antagonists - therapeutic use
African Continental Ancestry Group
Age Factors
Aged
Aged, 80 and over
Antiarythmic agents
Biological and medical sciences
Cardiac Output, Low - complications
Cardiovascular system
Contraindications
Diabetes Complications
Female
Heart attacks
Heart Failure - complications
Hospitals
Humans
Lung Diseases - complications
Male
Medical sciences
Mortality
Myocardial Infarction - complications
Myocardial Infarction - drug therapy
Myocardial Infarction - mortality
Pharmacology. Drug treatments
Prescription drugs
Proportional Hazards Models
Risk
Survival Analysis
Human
Infarct
Cardiovascular disease
Exploration
Coronary heart disease
Myocardial disease
Survival
Chemotherapy
Treatment
Follow up study
Myocardium
Left ventricle performance
Beta blocking agent
Ejection fraction
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Summary:Several large trials have demonstrated that the long-term administration of beta-adrenergic blockers to patients after myocardial infarction improves survival. 1 – 3 Although the percentage of such patients receiving beta-blockade has recently increased, physicians still reportedly prescribe beta-blockers for less than one third, 4 and cardiologists for less than half, 5 of patients with myocardial infarction. Older age, impaired left ventricular function, transient heart failure, and the use of diuretic drugs predict lack of use of these drugs. 6 This suggests that physicians are concerned that beta-blockers may be contraindicated in a substantial proportion of patients. The Cooperative Cardiovascular Project, a program to evaluate the . . .
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ISSN:0028-4793
1533-4406
DOI:10.1056/NEJM199808203390801