Visuoperceptual repetition priming and progression of parkinsonian signs in aging

• Published in: Neurobiology of aging Vol. 30; no. 3; pp. 441 - 449
• Main Authors: Fleischman, Debra A., Buchman, Aron S., Bienias, Julia L., Bennett, David A.
• Format: Journal Article
• Language: English
• Published: London Elsevier Inc 01.03.2009; Elsevier
• Subjects: Aged; Aged, 80 and over; Aging; Aging - physiology; Biological and medical sciences; Cross-Sectional Studies; Degenerative and inherited degenerative diseases of the nervous system. Leukodystrophies. Prion diseases; Development. Senescence. Regeneration. Transplantation; Disease Progression; Female; Follow-Up Studies; Fundamental and applied biological sciences. Psychology; Humans; Internal Medicine; Longitudinal Studies; Male; Medical sciences; Neurology; Neuropsychological Tests; Parkinson Disease - physiopathology; Parkinsonian signs; Reaction Time - physiology; Religious Orders Study; Repetition priming; Sensorimotor integration; Vertebrates: nervous system and sense organs; Visual Perception - physiology; Parkinsonian signs; Aging; Repetition priming; Sensorimotor integration; Religious Orders Study; Nervous system diseases; Senescence; Parkinson disease; Cerebral disorder; Sensorimotor coordination; Central nervous system disease; Degenerative disease; Extrapyramidal syndrome
• ISSN: 0197-4580; 1558-1497; 1558-1497
• DOI: 10.1016/j.neurobiolaging.2007.07.004

Parkinsonian signs in older persons are associated with numerous adverse health outcomes, however there is limited information about factors which predict progression of these signs. Using generalized linear models, we examined the association between efficiency in visuoperceptual and conceptual processing, measured by repetition priming, and rate of change in parkinsonian signs in a large sample of older persons without cognitive impairment or Parkinson's disease. Subjects with better visuoperceptual priming, measured by threshold word-identification and word-stem completion, at study baseline, progressed more slowly during follow-up of up to 11 years. Conceptual priming was not associated with change in parkinsonian signs. The findings demonstrate that individual differences in visuoperceptual processing efficiency, measured by repetition priming, occur in older persons without cognitive impairment and predict important changes in motor function. Reduced visuoperceptual priming in aging may be an early signal of vulnerability in a corticostrial circuit that contributes to sensorimotor integration.