Association between human adenovirus-36 and lipid disorders in Korean schoolchildren

• Published in: International Journal of Obesity Vol. 34; no. 1; pp. 89 - 93
• Main Authors: Na, H-N, Hong, Y-M, Kim, J, Kim, H-K, Jo, I, Nam, J-H
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 01.01.2010; Nature Publishing Group
• Subjects: Adenovirus Infections, Human - blood; Adenovirus Infections, Human - epidemiology; Adenovirus Infections, Human - virology; Adenoviruses; Adenoviruses, Human - immunology; Adolescent; Adults; Age; Antibodies; Antibodies, Viral - blood; Asian Continental Ancestry Group; ATP; Biological and medical sciences; Blood pressure; Body Mass Index; Body size; Care and treatment; Child; Child development; Cholesterol; Disorders; Disorders of blood lipids. Hyperlipoproteinemia; Drug dosages; Education; Epidemiology; Female; General aspects; Health aspects; Health Promotion and Disease Prevention; Humans; Internal Medicine; Korea - epidemiology; Lipid Metabolism Disorders - blood; Lipid Metabolism Disorders - epidemiology; Lipid Metabolism Disorders - virology; Lipids; Lipids - blood; Male; Medical schools; Medical sciences; Medicine; Medicine & Public Health; Metabolic Diseases; Metabolic disorders; Metabolic syndrome; Neutralization; Nutrition; Obesity; Obesity - blood; Obesity - epidemiology; Obesity - virology; Obesity in children; Odds Ratio; original-article; Overweight; Public Health; Risk Factors; Sex; Students; Task forces; Teenagers; Triglycerides; Asia; Korea; South Korea; United States > US; USA; human adenovirus-36; triglycerides; Korean schoolchildren; total cholesterol; lipid disorders; Adenoviridae; Lipids; Hyperlipoproteinemia; Lipoprotein; Association; Human adenovirus; Dyslipemia; Child; Nutritional status; Human; Obesity; Nutrition; Nutrition disorder; Korean; Metabolic diseases; Triglyceride; Cholesterol; Virus; School age; Hypercholesterolemia; Mastadenovirus
• ISSN: 0307-0565; 1476-5497
• DOI: 10.1038/ijo.2009.207

Background: Although the human adenovirus-36 (Ad-36) has been associated with obesity and related lipid disorders in the United States, this association has yet to be identified in other countries. Therefore, we tried to determine whether Ad-36 is associated with obesity or lipid disorders in Korean schoolchildren. Method: A total of 318 Korean schoolchildren aged 6–15 years, who participated in the Ewha Womans University Obesity Research Study, were selected for a community-based cohort study. Non-obese and obese were defined as body mass index (BMI) <85th and ⩾95th percentiles of the Korean reference BMI-for-age curves, respectively, according to International Obesity Task Force definitions. The cutoff points for lipid disorders were modified from the age-modified standards of the National Cholesterol Education Program (NCEP)-Adult Treatment Panel (ATP) III metabolic syndrome criteria. The Ad-36 antibody was measured using a serum neutralization assay. Results: More obese participants than non-obese participants tested positive for the Ad-36 antibody (28.57 vs 13.56%, respectively; P =0.0174). Within the obese group, the participants who tested positive for the Ad-36 antibody had higher levels of triglycerides (TG) and total cholesterol than those who tested negative for the Ad-36 antibody ( P <0.001). However, these associations were not present in the non-obese group. The unadjusted odds ratio (OR) for Ad-36 antibody positivity was greater in obese participants than non-obese participants (OR=2.550, 95% confidence interval (CI): 1.154–5.633). However, this OR seemed to be nonsignificant when age, sex and lipid variables were included in the analysis (OR=1.752, 95% CI: 0.763–4.020). The unadjusted OR for the elevated TG was significantly higher in participants who were Ad-36 antibody-positive than those who were Ad-36 antibody-negative (OR=2.511, 95% CI: 1.448–4.353). This trend remained constant even after adjustment for age, sex and obesity (OR=2.328, 95% CI: 1.296–4.181). Conclusion: Ad-36 seems to be strongly associated with lipid disorders in Korean schoolchildren regardless of obesity.