Neurobehavioral abnormalities in a brain-specific NADPH-cytochrome P450 reductase knockout mouse model

• Published in: Neuroscience Vol. 218; pp. 170 - 180
• Main Authors: Fang, C, Bolivar, V.J, Gu, J, Yang, W, Zeitlin, S.O, Ding, X
• Format: Journal Article
• Language: English
• Published: Amsterdam Elsevier Inc 30.08.2012; Elsevier
• Subjects: Animal models; Animals; Anxiety; Behavior, Animal - physiology; Biological and medical sciences; Brain; Brain - enzymology; Conditioning, Classical; cytochrome P450; Data processing; Enzymes; Exploratory behavior; Fear - physiology; Fear conditioning; Female; Foot shock; Fundamental and applied biological sciences. Psychology; Gene deletion; Male; Maze Learning; Memory; Memory - physiology; Mice; Mice, Knockout; NADPH-cytochrome P450 reductase; NADPH-ferrihemoprotein reductase; NADPH-Ferrihemoprotein Reductase - genetics; NADPH-Ferrihemoprotein Reductase - metabolism; Nervous system; Neurology; Pain perception; spatial memory; Vertebrates: nervous system and sense organs; heme oxygenase; calmodulin-dependent protein kinase IIα; fear conditioning; memory; CPR; brain specific Cpr-knockout; brain- Cpr-null; HO; cytochrome P450; brain; mice; Cre recombinase; CaMKIIα; analysis of variance; ANOVA; Cre; NADPH-cytochrome P450 reductase; P450; wild-type; WT; brain-Cpr-null; Animal model; Enzyme; Cytochrome P450; Memory; Rodentia; Central nervous system; NADPH-ferrihemoprotein reductase; Encephalon; Fear; Vertebrata; Mammalia; Mouse; Animal; Oxidoreductases; Conditioning; Mutation
• ISSN: 0306-4522; 1873-7544
• DOI: 10.1016/j.neuroscience.2012.05.027

Highlights ► Brain P450 reductase (CPR) is important in fear conditioning and memory. ► Brain- Cpr -null mice are more active than are wild-type in exploratory behavior assay. ► Brain- Cpr -null mice show deficit in activity suppression in fear-conditioning assay. ► Brain- Cpr -null mice have no change in pain threshold or spatial learning or memory.