Molecular and Functional Analysis of Cellular Phenomena Using Single-Cell Mass Spectrometry

• Published in: Biological & pharmaceutical bulletin Vol. 35; no. 9; pp. 1425 - 1431
• Main Authors: Tsuyama, Naohiro, Mizuno, Hajime, Masujima, Tsutomu
• Format: Journal Article
• Language: English; Japanese
• Published: Japan The Pharmaceutical Society of Japan 2012; Pharmaceutical Society of Japan; Japan Science and Technology Agency
• Subjects: cell heterogeneity; drug metabolism; Humans; Mass Spectrometry - methods; metabolome; Single-Cell Analysis - methods; single-cell mass spectrometry; Spectrometry, Mass, Electrospray Ionization - methods; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization - methods; Spectrometry, Mass, Secondary Ion - methods

Single-cell analysis has attracted attention in many fields of biological studies as a tool to survey the precise mechanisms of cellular and molecular behavior. The development of sensitive mass spectrometry allows the study of molecules in single cells or small regions. Matrix-assisted laser desorp...