Better safe than sorry?—On the influence of learned safety on pain perception
The experience of threat was found to result—mostly—in increased pain, however it is still unclear whether the exact opposite, namely the feeling of safety may lead to a reduction of pain. To test this hypothesis, we conducted two between-subject experiments (N = 94; N = 87), investigating whether l...
Saved in:
| Published in | PloS one Vol. 18; no. 11; p. e0289047 |
|---|---|
| Main Authors | , , , |
| Format | Journal Article |
| Language | English |
| Published |
San Francisco
Public Library of Science
07.11.2023
Public Library of Science (PLoS) |
| Subjects | |
| Online Access | Get full text |
Cover
Loading…
| Abstract | The experience of threat was found to result—mostly—in increased pain, however it is still unclear whether the exact opposite, namely the feeling of safety may lead to a reduction of pain. To test this hypothesis, we conducted two between-subject experiments (N = 94; N = 87), investigating whether learned safety relative to a neutral control condition can reduce pain, while threat should lead to increased pain compared to a neutral condition. Therefore, participants first underwent either threat or safety conditioning, before entering an identical test phase, where the previously conditioned threat or safety cue and a newly introduced visual cue were presented simultaneously with heat pain stimuli. Methodological changes were performed in experiment 2 to prevent safety extinction and to facilitate conditioning in the first place: We included additional verbal instructions, increased the maximum length of the ISI and raised CS-US contingency in the threat group from 50% to 75%. In addition to pain ratings and ratings of the visual cues (threat, safety, arousal, valence, and contingency), in both experiments, we collected heart rate and skin conductance. Analysis of the cue ratings during acquisition indicate successful threat and safety induction, however results of the test phase, when also heat pain was administered, demonstrate rapid safety extinction in both experiments. Results suggest rather small modulation of subjective and physiological pain responses following threat or safety cues relative to the neutral condition. However, exploratory analysis revealed reduced pain ratings in later trials of the experiment in the safety group compared to the threat group in both studies, suggesting different temporal dynamics for threat and safety learning and extinction, respectively.
Perspective
: The present results demonstrate the challenge to maintain safety in the presence of acute pain and suggest more research on the interaction of affective learning mechanism and pain processing. |
|---|---|
| AbstractList | The experience of threat was found to result-mostly-in increased pain, however it is still unclear whether the exact opposite, namely the feeling of safety may lead to a reduction of pain. To test this hypothesis, we conducted two between-subject experiments (N = 94; N = 87), investigating whether learned safety relative to a neutral control condition can reduce pain, while threat should lead to increased pain compared to a neutral condition. Therefore, participants first underwent either threat or safety conditioning, before entering an identical test phase, where the previously conditioned threat or safety cue and a newly introduced visual cue were presented simultaneously with heat pain stimuli. Methodological changes were performed in experiment 2 to prevent safety extinction and to facilitate conditioning in the first place: We included additional verbal instructions, increased the maximum length of the ISI and raised CS-US contingency in the threat group from 50% to 75%. In addition to pain ratings and ratings of the visual cues (threat, safety, arousal, valence, and contingency), in both experiments, we collected heart rate and skin conductance. Analysis of the cue ratings during acquisition indicate successful threat and safety induction, however results of the test phase, when also heat pain was administered, demonstrate rapid safety extinction in both experiments. Results suggest rather small modulation of subjective and physiological pain responses following threat or safety cues relative to the neutral condition. However, exploratory analysis revealed reduced pain ratings in later trials of the experiment in the safety group compared to the threat group in both studies, suggesting different temporal dynamics for threat and safety learning and extinction, respectively. Perspective: The present results demonstrate the challenge to maintain safety in the presence of acute pain and suggest more research on the interaction of affective learning mechanism and pain processing.The experience of threat was found to result-mostly-in increased pain, however it is still unclear whether the exact opposite, namely the feeling of safety may lead to a reduction of pain. To test this hypothesis, we conducted two between-subject experiments (N = 94; N = 87), investigating whether learned safety relative to a neutral control condition can reduce pain, while threat should lead to increased pain compared to a neutral condition. Therefore, participants first underwent either threat or safety conditioning, before entering an identical test phase, where the previously conditioned threat or safety cue and a newly introduced visual cue were presented simultaneously with heat pain stimuli. Methodological changes were performed in experiment 2 to prevent safety extinction and to facilitate conditioning in the first place: We included additional verbal instructions, increased the maximum length of the ISI and raised CS-US contingency in the threat group from 50% to 75%. In addition to pain ratings and ratings of the visual cues (threat, safety, arousal, valence, and contingency), in both experiments, we collected heart rate and skin conductance. Analysis of the cue ratings during acquisition indicate successful threat and safety induction, however results of the test phase, when also heat pain was administered, demonstrate rapid safety extinction in both experiments. Results suggest rather small modulation of subjective and physiological pain responses following threat or safety cues relative to the neutral condition. However, exploratory analysis revealed reduced pain ratings in later trials of the experiment in the safety group compared to the threat group in both studies, suggesting different temporal dynamics for threat and safety learning and extinction, respectively. Perspective: The present results demonstrate the challenge to maintain safety in the presence of acute pain and suggest more research on the interaction of affective learning mechanism and pain processing. The experience of threat was found to result—mostly—in increased pain, however it is still unclear whether the exact opposite, namely the feeling of safety may lead to a reduction of pain. To test this hypothesis, we conducted two between-subject experiments (N = 94; N = 87), investigating whether learned safety relative to a neutral control condition can reduce pain, while threat should lead to increased pain compared to a neutral condition. Therefore, participants first underwent either threat or safety conditioning, before entering an identical test phase, where the previously conditioned threat or safety cue and a newly introduced visual cue were presented simultaneously with heat pain stimuli. Methodological changes were performed in experiment 2 to prevent safety extinction and to facilitate conditioning in the first place: We included additional verbal instructions, increased the maximum length of the ISI and raised CS-US contingency in the threat group from 50% to 75%. In addition to pain ratings and ratings of the visual cues (threat, safety, arousal, valence, and contingency), in both experiments, we collected heart rate and skin conductance. Analysis of the cue ratings during acquisition indicate successful threat and safety induction, however results of the test phase, when also heat pain was administered, demonstrate rapid safety extinction in both experiments. Results suggest rather small modulation of subjective and physiological pain responses following threat or safety cues relative to the neutral condition. However, exploratory analysis revealed reduced pain ratings in later trials of the experiment in the safety group compared to the threat group in both studies, suggesting different temporal dynamics for threat and safety learning and extinction, respectively. Perspective : The present results demonstrate the challenge to maintain safety in the presence of acute pain and suggest more research on the interaction of affective learning mechanism and pain processing. The experience of threat was found to result-mostly-in increased pain, however it is still unclear whether the exact opposite, namely the feeling of safety may lead to a reduction of pain. To test this hypothesis, we conducted two between-subject experiments (N = 94; N = 87), investigating whether learned safety relative to a neutral control condition can reduce pain, while threat should lead to increased pain compared to a neutral condition. Therefore, participants first underwent either threat or safety conditioning, before entering an identical test phase, where the previously conditioned threat or safety cue and a newly introduced visual cue were presented simultaneously with heat pain stimuli. Methodological changes were performed in experiment 2 to prevent safety extinction and to facilitate conditioning in the first place: We included additional verbal instructions, increased the maximum length of the ISI and raised CS-US contingency in the threat group from 50% to 75%. In addition to pain ratings and ratings of the visual cues (threat, safety, arousal, valence, and contingency), in both experiments, we collected heart rate and skin conductance. Analysis of the cue ratings during acquisition indicate successful threat and safety induction, however results of the test phase, when also heat pain was administered, demonstrate rapid safety extinction in both experiments. Results suggest rather small modulation of subjective and physiological pain responses following threat or safety cues relative to the neutral condition. However, exploratory analysis revealed reduced pain ratings in later trials of the experiment in the safety group compared to the threat group in both studies, suggesting different temporal dynamics for threat and safety learning and extinction, respectively. Perspective: The present results demonstrate the challenge to maintain safety in the presence of acute pain and suggest more research on the interaction of affective learning mechanism and pain processing. The experience of threat was found to result-mostly-in increased pain, however it is still unclear whether the exact opposite, namely the feeling of safety may lead to a reduction of pain. To test this hypothesis, we conducted two between-subject experiments (N = 94; N = 87), investigating whether learned safety relative to a neutral control condition can reduce pain, while threat should lead to increased pain compared to a neutral condition. Therefore, participants first underwent either threat or safety conditioning, before entering an identical test phase, where the previously conditioned threat or safety cue and a newly introduced visual cue were presented simultaneously with heat pain stimuli. Methodological changes were performed in experiment 2 to prevent safety extinction and to facilitate conditioning in the first place: We included additional verbal instructions, increased the maximum length of the ISI and raised CS-US contingency in the threat group from 50% to 75%. In addition to pain ratings and ratings of the visual cues (threat, safety, arousal, valence, and contingency), in both experiments, we collected heart rate and skin conductance. Analysis of the cue ratings during acquisition indicate successful threat and safety induction, however results of the test phase, when also heat pain was administered, demonstrate rapid safety extinction in both experiments. Results suggest rather small modulation of subjective and physiological pain responses following threat or safety cues relative to the neutral condition. However, exploratory analysis revealed reduced pain ratings in later trials of the experiment in the safety group compared to the threat group in both studies, suggesting different temporal dynamics for threat and safety learning and extinction, respectively. The experience of threat was found to result—mostly—in increased pain, however it is still unclear whether the exact opposite, namely the feeling of safety may lead to a reduction of pain. To test this hypothesis, we conducted two between-subject experiments (N = 94; N = 87), investigating whether learned safety relative to a neutral control condition can reduce pain, while threat should lead to increased pain compared to a neutral condition. Therefore, participants first underwent either threat or safety conditioning, before entering an identical test phase, where the previously conditioned threat or safety cue and a newly introduced visual cue were presented simultaneously with heat pain stimuli. Methodological changes were performed in experiment 2 to prevent safety extinction and to facilitate conditioning in the first place: We included additional verbal instructions, increased the maximum length of the ISI and raised CS-US contingency in the threat group from 50% to 75%. In addition to pain ratings and ratings of the visual cues (threat, safety, arousal, valence, and contingency), in both experiments, we collected heart rate and skin conductance. Analysis of the cue ratings during acquisition indicate successful threat and safety induction, however results of the test phase, when also heat pain was administered, demonstrate rapid safety extinction in both experiments. Results suggest rather small modulation of subjective and physiological pain responses following threat or safety cues relative to the neutral condition. However, exploratory analysis revealed reduced pain ratings in later trials of the experiment in the safety group compared to the threat group in both studies, suggesting different temporal dynamics for threat and safety learning and extinction, respectively. Perspective : The present results demonstrate the challenge to maintain safety in the presence of acute pain and suggest more research on the interaction of affective learning mechanism and pain processing. |
| Audience | Academic |
| Author | Pauli, Paul Reicherts, Philipp Zillig, Anna-Lena Wieser, Matthias |
| AuthorAffiliation | Liverpool John Moores University, UNITED KINGDOM 1 Department of Psychology, University of Würzburg, Würzburg, Germany 2 Department of Clinical Psychology, Erasmus University of Rotterdam, Rotterdam, Netherlands 3 Department of Medical Psychology and Sociology, University of Augsburg, Augsburg, Germany |
| AuthorAffiliation_xml | – name: Liverpool John Moores University, UNITED KINGDOM – name: 2 Department of Clinical Psychology, Erasmus University of Rotterdam, Rotterdam, Netherlands – name: 1 Department of Psychology, University of Würzburg, Würzburg, Germany – name: 3 Department of Medical Psychology and Sociology, University of Augsburg, Augsburg, Germany |
| Author_xml | – sequence: 1 givenname: Anna-Lena orcidid: 0000-0002-3734-382X surname: Zillig fullname: Zillig, Anna-Lena – sequence: 2 givenname: Paul surname: Pauli fullname: Pauli, Paul – sequence: 3 givenname: Matthias surname: Wieser fullname: Wieser, Matthias – sequence: 4 givenname: Philipp surname: Reicherts fullname: Reicherts, Philipp |
| BookMark | eNqNkt2K1DAUx4us4O7oGwgWBNGLGdOmTRpvlnXxY2BhwK_bkKYnMxkyyZik4tz5ED6hT2K604XtsogEknDy-5-TnPzPshPrLGTZ0wItCkyL11vXeyvMYp_CC1Q2DFX0QXZaMFzOSYnwya39o-wshC1CNW4IOc1WbyFG8HkQCvK4ETYPzvvD-Z9fv1c2BSDXVpkerITcqdyA8Ba6azwecmfzvdBpAi9hH7Wzj7OHSpgAT8Z1ln19_-7L5cf51erD8vLiai4JRXFOBVKkg4rWHepaUZICqCwagqSoCClwh0WL2xorCg2q24q1VYkrrIhCHWspxbPs2THv3rjAxwYEjhFhZVJUdSKWR6JzYsv3Xu-EP3AnNL8OOL_mwkctDfBKkabFNaECoKplK5igqpQFsIISJodq52O1vt1BJ8FGL8wk6fTE6g1fux-8QKRkJN18lr0cM3j3vYcQ-U4HCcYIC64PvGwaWlGKWJnQ53fQ-583UmuRXpA-yaXCckjKLygtGCIENYla3EOl0cFOy2QXpVN8Ing1ESQmws-4Fn0IfPn50_-zq29T9sUtdgPCxE1wph88E6bgmyMovQvBg-JSRzFg6ebapI7ywfM3PeGD5_no-SSu7ohvvuifsr_lvQhz |
| CitedBy_id | crossref_primary_10_1123_kr_2024_0035 |
| Cites_doi | 10.1016/j.biopsycho.2008.01.007 10.1016/j.brat.2020.103635 10.1111/psyp.12251 10.1016/S0191-8869(00)00183-5 10.1016/j.beproc.2004.01.011 10.1016/j.nlm.2019.107127 10.1037/1040-3590.7.4.524 10.1016/B978-0-12-800538-5.00001-7 10.1007/s00115-006-2098-7 10.1016/j.pain.2013.02.012 10.1002/da.20663 10.1038/sj.npp.1300530 10.1037/0003-066X.50.5.372 10.1093/scan/nsw181 10.1016/j.biopsycho.2012.03.019 10.1146/annurev.psych.121208.131631 10.1371/journal.pone.0005865 10.1016/j.neuroimage.2009.09.040 10.1073/pnas.0913384107 10.1523/JNEUROSCI.2260-06.2006 10.1026/0012-1924.55.4.223 10.1016/S0304-3959(03)00119-2 10.1038/nrn3516 10.55782/ane-1995-1067 10.1038/npp.2013.191 10.1016/j.neubiorev.2017.02.026 10.1007/978-3-642-12783-0 10.1007/978-3-662-50512-0_3 10.1016/j.brat.2008.10.017 10.1016/j.pain.2012.06.017 10.1073/pnas.0904706106 10.1007/s10943-006-9068-z 10.1016/j.neuroimage.2009.05.059 10.1016/j.neuron.2008.07.041 10.1016/j.biopsycho.2015.10.007 10.1080/13644360903565524 10.1016/j.jpain.2017.02.430 10.1016/j.pain.2008.09.018 10.1016/j.jpsychores.2007.12.004 10.1002/ejp.676 10.1016/j.pneurobio.2009.04.003 10.1037/0022-3514.78.2.350 10.1111/j.1469-8986.2005.00310.x 10.1037/1528-3542.1.3.276 10.1037/0022-3514.67.6.1063 10.1016/0304-3959(83)90126-4 10.1515/sjpain-2019-0025 10.1016/j.neuron.2005.02.017 10.1027//0269-8803.13.2.83 10.1101/lm.74704 10.1016/j.pain.2009.11.018 10.1016/j.pain.2009.06.020 10.1016/0896-6273(95)90070-5 10.3109/08990229509063142 10.3109/07853890903583666 10.1016/S0304-3959(99)00183-9 10.1002/ejp.539 10.1055/s-2008-1067425 10.1093/scan/nsw173 10.1016/0005-7916(94)90063-9 10.1026/0943-8149.16.1.26 10.1111/j.1469-8986.2009.00835.x 10.1016/j.pain.2010.11.032 10.1037/0735-7044.120.5.995 |
| ContentType | Journal Article |
| Copyright | COPYRIGHT 2023 Public Library of Science 2023 Zillig et al. This is an open access article distributed under the terms of the Creative Commons Attribution License: http://creativecommons.org/licenses/by/4.0/ (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License. Copyright: © 2023 Zillig et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. 2023 Zillig et al 2023 Zillig et al 2023 Zillig et al. This is an open access article distributed under the terms of the Creative Commons Attribution License: http://creativecommons.org/licenses/by/4.0/ (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License. |
| Copyright_xml | – notice: COPYRIGHT 2023 Public Library of Science – notice: 2023 Zillig et al. This is an open access article distributed under the terms of the Creative Commons Attribution License: http://creativecommons.org/licenses/by/4.0/ (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License. – notice: Copyright: © 2023 Zillig et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. – notice: 2023 Zillig et al 2023 Zillig et al – notice: 2023 Zillig et al. This is an open access article distributed under the terms of the Creative Commons Attribution License: http://creativecommons.org/licenses/by/4.0/ (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License. |
| DBID | AAYXX CITATION IOV ISR 3V. 7QG 7QL 7QO 7RV 7SN 7SS 7T5 7TG 7TM 7U9 7X2 7X7 7XB 88E 8AO 8C1 8FD 8FE 8FG 8FH 8FI 8FJ 8FK ABJCF ABUWG AEUYN AFKRA ARAPS ATCPS AZQEC BBNVY BENPR BGLVJ BHPHI C1K CCPQU D1I DWQXO FR3 FYUFA GHDGH GNUQQ H94 HCIFZ K9. KB. KB0 KL. L6V LK8 M0K M0S M1P M7N M7P M7S NAPCQ P5Z P62 P64 PATMY PDBOC PHGZM PHGZT PIMPY PJZUB PKEHL PPXIY PQEST PQGLB PQQKQ PQUKI PTHSS PYCSY RC3 7X8 5PM DOA |
| DOI | 10.1371/journal.pone.0289047 |
| DatabaseName | CrossRef Gale In Context: Opposing Viewpoints Gale In Context: Science ProQuest Central (Corporate) Animal Behavior Abstracts Bacteriology Abstracts (Microbiology B) Biotechnology Research Abstracts Nursing & Allied Health Database Ecology Abstracts Entomology Abstracts (Full archive) Immunology Abstracts Meteorological & Geoastrophysical Abstracts Nucleic Acids Abstracts Virology and AIDS Abstracts Agricultural Science Collection Health & Medical Collection ProQuest Central (purchase pre-March 2016) Medical Database (Alumni Edition) ProQuest Pharma Collection Public Health Database Technology Research Database ProQuest SciTech Collection ProQuest Technology Collection ProQuest Natural Science Journals ProQuest Hospital Collection Hospital Premium Collection (Alumni Edition) ProQuest Central (Alumni) (purchase pre-March 2016) Materials Science & Engineering Collection ProQuest Central (Alumni) ProQuest One Sustainability ProQuest Central UK/Ireland Advanced Technologies & Aerospace Collection Agricultural & Environmental Science Collection ProQuest Central Essentials Biological Science Collection ProQuest Central ProQuest Technology Collection Natural Science Collection Environmental Sciences and Pollution Management ProQuest One Community College ProQuest Materials Science Collection ProQuest Central Engineering Research Database Health Research Premium Collection Health Research Premium Collection (Alumni) ProQuest Central Student AIDS and Cancer Research Abstracts ProQuest SciTech Premium Collection ProQuest Health & Medical Complete (Alumni) Materials Science Database Nursing & Allied Health Database (Alumni Edition) Meteorological & Geoastrophysical Abstracts - Academic ProQuest Engineering Collection Biological Sciences Agricultural Science Database ProQuest Health & Medical Collection Medical Database Algology Mycology and Protozoology Abstracts (Microbiology C) Biological Science Database Engineering Database Nursing & Allied Health Premium Advanced Technologies & Aerospace Database ProQuest Advanced Technologies & Aerospace Collection Biotechnology and BioEngineering Abstracts Environmental Science Database Materials Science Collection ProQuest Central Premium ProQuest One Academic (New) ProQuest Publicly Available Content Database ProQuest Health & Medical Research Collection ProQuest One Academic Middle East (New) ProQuest One Health & Nursing ProQuest One Academic Eastern Edition (DO NOT USE) ProQuest One Applied & Life Sciences ProQuest One Academic ProQuest One Academic UKI Edition Engineering Collection Environmental Science Collection Genetics Abstracts MEDLINE - Academic PubMed Central (Full Participant titles) DOAJ Directory of Open Access Journals |
| DatabaseTitle | CrossRef Agricultural Science Database Publicly Available Content Database ProQuest Central Student ProQuest Advanced Technologies & Aerospace Collection ProQuest Central Essentials Nucleic Acids Abstracts SciTech Premium Collection Environmental Sciences and Pollution Management ProQuest One Applied & Life Sciences ProQuest One Sustainability Health Research Premium Collection Meteorological & Geoastrophysical Abstracts Natural Science Collection Health & Medical Research Collection Biological Science Collection ProQuest Central (New) ProQuest Medical Library (Alumni) Engineering Collection Advanced Technologies & Aerospace Collection Engineering Database Virology and AIDS Abstracts ProQuest Biological Science Collection ProQuest One Academic Eastern Edition Agricultural Science Collection ProQuest Hospital Collection ProQuest Technology Collection Health Research Premium Collection (Alumni) Biological Science Database Ecology Abstracts ProQuest Hospital Collection (Alumni) Biotechnology and BioEngineering Abstracts Environmental Science Collection Entomology Abstracts Nursing & Allied Health Premium ProQuest Health & Medical Complete ProQuest One Academic UKI Edition Environmental Science Database ProQuest Nursing & Allied Health Source (Alumni) Engineering Research Database ProQuest One Academic Meteorological & Geoastrophysical Abstracts - Academic ProQuest One Academic (New) Technology Collection Technology Research Database ProQuest One Academic Middle East (New) Materials Science Collection ProQuest Health & Medical Complete (Alumni) ProQuest Central (Alumni Edition) ProQuest One Community College ProQuest One Health & Nursing ProQuest Natural Science Collection ProQuest Pharma Collection ProQuest Central ProQuest Health & Medical Research Collection Genetics Abstracts ProQuest Engineering Collection Biotechnology Research Abstracts Health and Medicine Complete (Alumni Edition) ProQuest Central Korea Bacteriology Abstracts (Microbiology B) Algology Mycology and Protozoology Abstracts (Microbiology C) Agricultural & Environmental Science Collection AIDS and Cancer Research Abstracts Materials Science Database ProQuest Materials Science Collection ProQuest Public Health ProQuest Nursing & Allied Health Source ProQuest SciTech Collection Advanced Technologies & Aerospace Database ProQuest Medical Library Animal Behavior Abstracts Materials Science & Engineering Collection Immunology Abstracts ProQuest Central (Alumni) MEDLINE - Academic |
| DatabaseTitleList | MEDLINE - Academic CrossRef Agricultural Science Database |
| Database_xml | – sequence: 1 dbid: DOA name: DOAJ Open Access Journals url: https://www.doaj.org/ sourceTypes: Open Website – sequence: 2 dbid: 8FG name: ProQuest Technology Collection url: https://search.proquest.com/technologycollection1 sourceTypes: Aggregation Database |
| DeliveryMethod | fulltext_linktorsrc |
| Discipline | Sciences (General) |
| DocumentTitleAlternate | On the influence of learned safety on pain perception |
| EISSN | 1932-6203 |
| ExternalDocumentID | 3069280545 oai_doaj_org_article_4f68b3567aee45cba9a7f2c1e91769c7 PMC10629634 A771906608 10_1371_journal_pone_0289047 |
| GeographicLocations | Germany |
| GeographicLocations_xml | – name: Germany |
| GrantInformation_xml | – fundername: ; – fundername: ; grantid: DE 134187690 |
| GroupedDBID | --- 123 29O 2WC 53G 5VS 7RV 7X2 7X7 7XC 88E 8AO 8C1 8CJ 8FE 8FG 8FH 8FI 8FJ A8Z AAFWJ AAUCC AAWOE AAYXX ABDBF ABIVO ABJCF ABUWG ACGFO ACIHN ACIWK ACPRK ACUHS ADBBV AEAQA AENEX AEUYN AFKRA AFPKN AFRAH AHMBA ALIPV ALMA_UNASSIGNED_HOLDINGS AOIJS APEBS ARAPS ATCPS BAWUL BBNVY BCNDV BENPR BGLVJ BHPHI BKEYQ BPHCQ BVXVI BWKFM CCPQU CITATION CS3 D1I D1J D1K DIK DU5 E3Z EAP EAS EBD EMOBN ESX EX3 F5P FPL FYUFA GROUPED_DOAJ GX1 HCIFZ HH5 HMCUK HYE IAO IEA IGS IHR IHW INH INR IOV IPY ISE ISR ITC K6- KB. KQ8 L6V LK5 LK8 M0K M1P M48 M7P M7R M7S M~E NAPCQ O5R O5S OK1 OVT P2P P62 PATMY PDBOC PHGZM PHGZT PIMPY PQQKQ PROAC PSQYO PTHSS PV9 PYCSY RNS RPM RZL SV3 TR2 UKHRP WOQ WOW ~02 ~KM BBORY PMFND 3V. 7QG 7QL 7QO 7SN 7SS 7T5 7TG 7TM 7U9 7XB 8FD 8FK AZQEC C1K DWQXO FR3 GNUQQ H94 K9. KL. M7N P64 PJZUB PKEHL PPXIY PQEST PQGLB PQUKI RC3 7X8 5PM PUEGO |
| ID | FETCH-LOGICAL-c670t-7a0f6de475d0dba261e7c1860ca46613d3ab3b53f7e805b49b42343f6f0d9b773 |
| IEDL.DBID | M48 |
| ISSN | 1932-6203 |
| IngestDate | Wed Aug 13 01:19:03 EDT 2025 Wed Aug 27 00:54:00 EDT 2025 Thu Aug 21 18:36:13 EDT 2025 Fri Jul 11 03:51:46 EDT 2025 Fri Jul 25 11:22:52 EDT 2025 Tue Jun 17 22:18:27 EDT 2025 Tue Jun 10 21:15:27 EDT 2025 Fri Jun 27 05:30:19 EDT 2025 Fri Jun 27 06:07:13 EDT 2025 Thu May 22 21:20:02 EDT 2025 Tue Jul 01 03:36:03 EDT 2025 Thu Apr 24 23:03:29 EDT 2025 |
| IsDoiOpenAccess | true |
| IsOpenAccess | true |
| IsPeerReviewed | true |
| IsScholarly | true |
| Issue | 11 |
| Language | English |
| License | This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Creative Commons Attribution License |
| LinkModel | DirectLink |
| MergedId | FETCHMERGED-LOGICAL-c670t-7a0f6de475d0dba261e7c1860ca46613d3ab3b53f7e805b49b42343f6f0d9b773 |
| Notes | ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 14 content type line 23 Competing Interests: The authors have declared that no competing interests exist. |
| ORCID | 0000-0002-3734-382X |
| OpenAccessLink | https://www.proquest.com/docview/3069280545?pq-origsite=%requestingapplication% |
| PQID | 3069280545 |
| PQPubID | 1436336 |
| PageCount | e0289047 |
| ParticipantIDs | plos_journals_3069280545 doaj_primary_oai_doaj_org_article_4f68b3567aee45cba9a7f2c1e91769c7 pubmedcentral_primary_oai_pubmedcentral_nih_gov_10629634 proquest_miscellaneous_2887477092 proquest_journals_3069280545 gale_infotracmisc_A771906608 gale_infotracacademiconefile_A771906608 gale_incontextgauss_ISR_A771906608 gale_incontextgauss_IOV_A771906608 gale_healthsolutions_A771906608 crossref_citationtrail_10_1371_journal_pone_0289047 crossref_primary_10_1371_journal_pone_0289047 |
| ProviderPackageCode | CITATION AAYXX |
| PublicationCentury | 2000 |
| PublicationDate | 2023-11-07 |
| PublicationDateYYYYMMDD | 2023-11-07 |
| PublicationDate_xml | – month: 11 year: 2023 text: 2023-11-07 day: 07 |
| PublicationDecade | 2020 |
| PublicationPlace | San Francisco |
| PublicationPlace_xml | – name: San Francisco – name: San Francisco, CA USA |
| PublicationTitle | PloS one |
| PublicationYear | 2023 |
| Publisher | Public Library of Science Public Library of Science (PLoS) |
| Publisher_xml | – name: Public Library of Science – name: Public Library of Science (PLoS) |
| References | MJ Wieser (pone.0289047.ref050) 2012; 90 H Glaesmer (pone.0289047.ref063) 2008; 16 CJ Kemper (pone.0289047.ref071) 2009; 55 S Van Damme (pone.0289047.ref051) 2010; 34 TB Lonsdorf (pone.0289047.ref026) 2017; 77 MR Milad (pone.0289047.ref046) 2012; 63 M-L Mechias (pone.0289047.ref042) 2010; 49 ML Loggia (pone.0289047.ref039) 2011; 152 A Cándido (pone.0289047.ref017) 2004; 66 JL Rhudy (pone.0289047.ref014) 2003; 104 SA Josselyn (pone.0289047.ref024) 2005; 30 M Roy (pone.0289047.ref011) 2009; 106 S Lautenbacher (pone.0289047.ref034) 1995; 12 A Büssing (pone.0289047.ref065) 2007 P Reicherts (pone.0289047.ref009) 2013; 154 MJL Sullivan (pone.0289047.ref060) 1995; 7 S Lissek (pone.0289047.ref054) 2009; 47 JL Rhudy (pone.0289047.ref019) 2010; 148 HW Krohne (pone.0289047.ref057) 1996; 42 RK Butler (pone.0289047.ref013) 2009; 88 DD Pollak (pone.0289047.ref016) 2008; 60 B Kröner-Herwig (pone.0289047.ref031) 2011 MF Scheier (pone.0289047.ref062) 1994; 67 C Roy (pone.0289047.ref010) 2015; 19 KM Myers (pone.0289047.ref045) 2004; 11 J Hur (pone.0289047.ref043) 2016; 121 MM Bradley (pone.0289047.ref040) 1994; 25 C Bushnell (pone.0289047.ref001) 2013; 14 F Godinho (pone.0289047.ref049) 2006; 26 G Walasek (pone.0289047.ref018) 1995; 55 R Torrubia (pone.0289047.ref068) 2001; 31 R Kenntner‐Mabiala (pone.0289047.ref007) 2005; 42 A Büssing (pone.0289047.ref064) 2010; 15 K Meyer (pone.0289047.ref059) 2008; 64 R Kenntner-Mabiala (pone.0289047.ref006) 2008; 78 JL Rhudy (pone.0289047.ref029) 2009; 46 S Becker (pone.0289047.ref005) 2017; 12 C Horn-Hofmann (pone.0289047.ref033) 2015; 19 F Faul (pone.0289047.ref032) 2009; 41 C Kühner (pone.0289047.ref067) 2007; 78 P Reicherts (pone.0289047.ref002) 2017; 12 M Hautzinger (pone.0289047.ref066) 2006 G Koers (pone.0289047.ref038) 1999; 13 CM Klinke (pone.0289047.ref052) 2020; 167 PJ Lang (pone.0289047.ref020) 1995; 50 R Ruscheweyh (pone.0289047.ref058) 2009; 146 DD Pollak (pone.0289047.ref021) 2010; 42 RC Fraley (pone.0289047.ref070) 2000; 78 S Duschek (pone.0289047.ref012) 2019; 20 C Sehlmeyer (pone.0289047.ref028) 2009; 4 T Jovanovic (pone.0289047.ref044) 2010; 27 A. Meulders (pone.0289047.ref048) 2020; 131 L Laux (pone.0289047.ref055) 1981 DS Harvie (pone.0289047.ref053) 2017; 18 MT Rogan (pone.0289047.ref023) 1995; 15 E Kong (pone.0289047.ref025) 2014; 39 W Magerl (pone.0289047.ref036) 2017 LE Ostroff (pone.0289047.ref022) 2010; 107 BW Smith (pone.0289047.ref035) 2008; 140 F Bublatzky (pone.0289047.ref027) 2014; 51 J Ehrenthal (pone.0289047.ref069) 2009; 59 MT Rogan (pone.0289047.ref015) 2005; 46 K Wiech (pone.0289047.ref004) 2009; 47 CD Spielberger (pone.0289047.ref056) 1983 T Jovanovic (pone.0289047.ref041) 2006; 120 DD Price (pone.0289047.ref037) 1983; 17 MJ Wieser (pone.0289047.ref047) 2016 MM Bradley (pone.0289047.ref030) 2001; 1 J Schumacher (pone.0289047.ref061) 2005; 53 J Rhudy (pone.0289047.ref003) 2000; 84 P Reicherts (pone.0289047.ref008) 2012; 153 |
| References_xml | – volume: 78 start-page: 114 issue: 1 year: 2008 ident: pone.0289047.ref006 article-title: Distinct effects of attention and affect on pain perception and somatosensory evoked potentials publication-title: Biological psychology doi: 10.1016/j.biopsycho.2008.01.007 – volume: 131 start-page: 103635 year: 2020 ident: pone.0289047.ref048 article-title: Fear in the context of pain: Lessons learned from 100 years of fear conditioning research publication-title: Behaviour research and therapy doi: 10.1016/j.brat.2020.103635 – volume: 51 start-page: 1005 issue: 10 year: 2014 ident: pone.0289047.ref027 article-title: The persistence of socially instructed threat: Two threat-of-shock studies publication-title: Psychophysiology doi: 10.1111/psyp.12251 – volume: 53 start-page: 16 issue: 1 year: 2005 ident: pone.0289047.ref061 article-title: Die Resilienzskala–Ein Fragebogen zur Erfassung der psychischen Widerstandsfähigkeit als Personmerkmal publication-title: Zeitschrift für Klinische Psychologie, Psychiatrie und Psychotherapie – volume: 31 start-page: 837 issue: 6 year: 2001 ident: pone.0289047.ref068 article-title: The Sensitivity to Punishment and Sensitivity to Reward Questionnaire (SPSRQ) as a measure of Gray’s anxiety and impulsivity dimensions publication-title: Personality and Individual Differences doi: 10.1016/S0191-8869(00)00183-5 – volume: 66 start-page: 153 issue: 2 year: 2004 ident: pone.0289047.ref017 article-title: Safety signals from avoidance learning but not from yoked classical conditioning training pass both summation and retardation tests for inhibition publication-title: Behavioural processes doi: 10.1016/j.beproc.2004.01.011 – volume: 167 start-page: 107127 year: 2020 ident: pone.0289047.ref052 article-title: Evidence for impaired extinction learning in humans after distal stress exposure publication-title: Neurobiology of learning and memory doi: 10.1016/j.nlm.2019.107127 – volume-title: Theoretische Grundlagen und Handanweisung year: 1981 ident: pone.0289047.ref055 – volume: 7 start-page: 524 issue: 4 year: 1995 ident: pone.0289047.ref060 article-title: The Pain Catastrophizing Scale: Development and validation publication-title: Psychological Assessment doi: 10.1037/1040-3590.7.4.524 – start-page: 3 volume-title: The neuroscience of pain, stress, and emotion: Psychological and clinical implications year: 2016 ident: pone.0289047.ref047 doi: 10.1016/B978-0-12-800538-5.00001-7 – volume: 78 start-page: 651 issue: 6 year: 2007 ident: pone.0289047.ref067 article-title: Reliabilität und Validität des revidierten Beck-Depressionsinventars (BDI-II) publication-title: Nervenarzt doi: 10.1007/s00115-006-2098-7 – volume: 154 start-page: 793 issue: 6 year: 2013 ident: pone.0289047.ref009 article-title: On the mutual effects of pain and emotion: facial pain expressions enhance pain perception and vice versa are perceived as more arousing when feeling pain publication-title: Pain doi: 10.1016/j.pain.2013.02.012 – volume: 27 start-page: 244 issue: 3 year: 2010 ident: pone.0289047.ref044 article-title: Impaired fear inhibition is a biomarker of PTSD but not depression publication-title: Depression and anxiety doi: 10.1002/da.20663 – volume: 30 start-page: 17 issue: 1 year: 2005 ident: pone.0289047.ref024 article-title: The nucleus accumbens is not critically involved in mediating the effects of a safety signal on behavior publication-title: Neuropsychopharmacology doi: 10.1038/sj.npp.1300530 – volume: 50 start-page: 372 issue: 5 year: 1995 ident: pone.0289047.ref020 article-title: The emotion probe: studies of motivation and attention publication-title: American psychologist doi: 10.1037/0003-066X.50.5.372 – volume: 12 start-page: 544 issue: 4 year: 2017 ident: pone.0289047.ref002 article-title: Anxious anticipation and pain: the influence of instructed vs conditioned threat on pain publication-title: Soc Cogn Affect Neurosci doi: 10.1093/scan/nsw181 – volume: 90 start-page: 242 issue: 3 year: 2012 ident: pone.0289047.ref050 article-title: Tonic pain grabs attention, but leaves the processing of facial expressions intact-evidence from event-related brain potentials publication-title: Biol Psychol doi: 10.1016/j.biopsycho.2012.03.019 – volume: 63 start-page: 129 year: 2012 ident: pone.0289047.ref046 article-title: Fear extinction as a model for translational neuroscience: ten years of progress publication-title: Annu Rev Psychol doi: 10.1146/annurev.psych.121208.131631 – volume: 4 issue: 6 year: 2009 ident: pone.0289047.ref028 article-title: Human fear conditioning and extinction in neuroimaging: a systematic review publication-title: PloS one doi: 10.1371/journal.pone.0005865 – volume: 49 start-page: 1760 issue: 2 year: 2010 ident: pone.0289047.ref042 article-title: A meta-analysis of instructed fear studies: Implications for conscious appraisal of threat publication-title: NeuroImage doi: 10.1016/j.neuroimage.2009.09.040 – volume: 107 start-page: 9418 issue: 20 year: 2010 ident: pone.0289047.ref022 article-title: Fear and safety learning differentially affect synapse size and dendritic translation in the lateral amygdala publication-title: Proceedings of the National Academy of Sciences doi: 10.1073/pnas.0913384107 – volume: 26 start-page: 11454 issue: 44 year: 2006 ident: pone.0289047.ref049 article-title: Emotional Modulation of Pain: Is It the Sensation or What We Recall? publication-title: The Journal of Neuroscience doi: 10.1523/JNEUROSCI.2260-06.2006 – volume: 55 start-page: 223 issue: 4 year: 2009 ident: pone.0289047.ref071 article-title: Überprüfung der psychometrischen Qualität der deutschen Version des Angstsensitivitätsindex-3 publication-title: Diagnostica doi: 10.1026/0012-1924.55.4.223 – volume: 104 start-page: 617 issue: 3 year: 2003 ident: pone.0289047.ref014 article-title: Negative affect: effects on an evaluative measure of human pain publication-title: Pain doi: 10.1016/S0304-3959(03)00119-2 – volume: 14 start-page: 502 issue: 7 year: 2013 ident: pone.0289047.ref001 article-title: Cognitive and emotional control of pain and its disruption in chronic pain publication-title: Nat Rev Neurosci doi: 10.1038/nrn3516 – volume: 55 start-page: 121 year: 1995 ident: pone.0289047.ref018 article-title: Conditioning of fear and conditioning of safety in rats publication-title: Acta neurobiologiae experimentalis doi: 10.55782/ane-1995-1067 – volume: 39 start-page: 515 issue: 3 year: 2014 ident: pone.0289047.ref025 article-title: Learning not to fear: neural correlates of learned safety publication-title: Neuropsychopharmacology doi: 10.1038/npp.2013.191 – volume: 77 start-page: 247 year: 2017 ident: pone.0289047.ref026 article-title: Don’t fear ‘fear conditioning’: Methodological considerations for the design and analysis of studies on human fear acquisition, extinction, and return of fear publication-title: Neuroscience & Biobehavioral Reviews doi: 10.1016/j.neubiorev.2017.02.026 – start-page: 12783 volume-title: Schmerzpsychotherapie year: 2011 ident: pone.0289047.ref031 doi: 10.1007/978-3-642-12783-0 – start-page: 31 volume-title: Schmerzpsychotherapie year: 2017 ident: pone.0289047.ref036 doi: 10.1007/978-3-662-50512-0_3 – volume: 47 start-page: 111 issue: 2 year: 2009 ident: pone.0289047.ref054 article-title: Impaired discriminative fear-conditioning resulting from elevated fear responding to learned safety cues among individuals with panic disorder publication-title: Behaviour research and therapy doi: 10.1016/j.brat.2008.10.017 – volume: 153 start-page: 1959 issue: 9 year: 2012 ident: pone.0289047.ref008 article-title: Electrocortical evidence for preferential processing of dynamic pain expressions compared to other emotional expressions publication-title: Pain doi: 10.1016/j.pain.2012.06.017 – volume: 106 start-page: 20900 issue: 49 year: 2009 ident: pone.0289047.ref011 article-title: Cerebral and spinal modulation of pain by emotions publication-title: Proceedings of the National Academy of Sciences doi: 10.1073/pnas.0904706106 – start-page: 267 year: 2007 ident: pone.0289047.ref065 article-title: Distinct Expressions of Vital Spirituality" The ASP Questionnaire as an Explorative Research Tool" publication-title: Journal of Religion Health doi: 10.1007/s10943-006-9068-z – volume: 47 start-page: 987 issue: 3 year: 2009 ident: pone.0289047.ref004 article-title: The influence of negative emotions on pain: behavioral effects and neural mechanisms publication-title: Neuroimage doi: 10.1016/j.neuroimage.2009.05.059 – volume: 60 start-page: 149 issue: 1 year: 2008 ident: pone.0289047.ref016 article-title: An animal model of a behavioral intervention for depression publication-title: Neuron doi: 10.1016/j.neuron.2008.07.041 – volume: 121 start-page: 213 year: 2016 ident: pone.0289047.ref043 article-title: Emotion–attention interactions in fear conditioning: Moderation by executive load, neuroticism, and awareness publication-title: Biological psychology doi: 10.1016/j.biopsycho.2015.10.007 – year: 2006 ident: pone.0289047.ref066 publication-title: Beck-Depressions-Inventar: Revision: Harcourt Test Services – volume: 15 start-page: 25 issue: 1 year: 2010 ident: pone.0289047.ref064 article-title: Aspects of spirituality in adolescents publication-title: International Journal of Children’s Spirituality doi: 10.1080/13644360903565524 – volume: 18 start-page: 889 issue: 8 year: 2017 ident: pone.0289047.ref053 article-title: Classical Conditioning Differences Associated With Chronic Pain: A Systematic Review publication-title: The Journal of Pain doi: 10.1016/j.jpain.2017.02.430 – volume: 34 start-page: 204 issue: 2 year: 2010 ident: pone.0289047.ref051 publication-title: Keeping pain in mind: a motivational account of attention to pain – volume: 140 start-page: 420 issue: 3 year: 2008 ident: pone.0289047.ref035 article-title: Habituation and sensitization to heat and cold pain in women with fibromyalgia and healthy controls publication-title: Pain doi: 10.1016/j.pain.2008.09.018 – volume: 64 start-page: 469 issue: 5 year: 2008 ident: pone.0289047.ref059 article-title: Cross-cultural adaptation, reliability, and validity of the German version of the Pain Catastrophizing Scale publication-title: Journal of Psychosomatic Research doi: 10.1016/j.jpsychores.2007.12.004 – volume: 19 start-page: 852 issue: 6 year: 2015 ident: pone.0289047.ref010 article-title: Efficient information for recognizing pain in facial expressions publication-title: European Journal of Pain doi: 10.1002/ejp.676 – volume: 88 start-page: 184 issue: 3 year: 2009 ident: pone.0289047.ref013 article-title: Stress-induced analgesia publication-title: Prog Neurobiol doi: 10.1016/j.pneurobio.2009.04.003 – volume: 78 start-page: 350 issue: 2 year: 2000 ident: pone.0289047.ref070 article-title: An item response theory analysis of self-report measures of adult attachment publication-title: Journal of personality and social psychology doi: 10.1037/0022-3514.78.2.350 – volume: 42 start-page: 559 issue: 5 year: 2005 ident: pone.0289047.ref007 article-title: Affective modulation of brain potentials to painful and nonpainful stimuli publication-title: Psychophysiology doi: 10.1111/j.1469-8986.2005.00310.x – volume: 1 start-page: 276 issue: 3 year: 2001 ident: pone.0289047.ref030 article-title: Emotion and Motivation I: Defensive and Appetitive Reactions in Picture Processing publication-title: Emotion doi: 10.1037/1528-3542.1.3.276 – volume: 67 start-page: 1063 year: 1994 ident: pone.0289047.ref062 article-title: Distinguishing optimism from neuroticism (and trait anxiety, self-mastery, and self-esteem): A re-evaluation of the Life Orientation Test publication-title: Journal of Personality and Social Psychology doi: 10.1037/0022-3514.67.6.1063 – volume: 17 start-page: 45 issue: 1 year: 1983 ident: pone.0289047.ref037 article-title: The Validation of Visual Analog Scales as Ratio Scale Measures for Chronic and Experimental Pain publication-title: Pain doi: 10.1016/0304-3959(83)90126-4 – volume: 20 start-page: 205 issue: 1 year: 2019 ident: pone.0289047.ref012 article-title: Dispositional empathy is associated with experimental pain reduction during provision of social support by romantic partners publication-title: Scandinavian Journal of Pain doi: 10.1515/sjpain-2019-0025 – volume: 46 start-page: 309 issue: 2 year: 2005 ident: pone.0289047.ref015 article-title: Distinct neural signatures for safety and danger in the amygdala and striatum of the mouse publication-title: Neuron doi: 10.1016/j.neuron.2005.02.017 – volume: 13 start-page: 83 issue: 2 year: 1999 ident: pone.0289047.ref038 article-title: The computation of evoked heart rate and blood pressure publication-title: Journal of Psychophysiology doi: 10.1027//0269-8803.13.2.83 – volume: 11 start-page: 464 issue: 4 year: 2004 ident: pone.0289047.ref045 article-title: AX+, BX-discrimination learning in the fear-potentiated startle paradigm: possible relevance to inhibitory fear learning in extinction publication-title: Learning & Memory doi: 10.1101/lm.74704 – volume: 148 start-page: 320 issue: 2 year: 2010 ident: pone.0289047.ref019 article-title: Habituation, sensitization, and emotional valence modulation of pain responses publication-title: Pain doi: 10.1016/j.pain.2009.11.018 – volume: 146 start-page: 65 issue: 1 year: 2009 ident: pone.0289047.ref058 article-title: Pain sensitivity can be assessed by self-rating: Development and validation of the Pain Sensitivity Questionnaire publication-title: Pain doi: 10.1016/j.pain.2009.06.020 – volume: 15 start-page: 127 issue: 1 year: 1995 ident: pone.0289047.ref023 article-title: LTP is accompanied by commensurate enhancement of auditory-evoked responses in a fear conditioning circuit publication-title: Neuron doi: 10.1016/0896-6273(95)90070-5 – volume: 12 start-page: 59 issue: 1 year: 1995 ident: pone.0289047.ref034 article-title: Tonic pain evoked by pulsating heat: temporal summation mechanisms and perceptual qualities publication-title: Somatosensory & motor research doi: 10.3109/08990229509063142 – volume: 41 start-page: 1149 issue: 4 year: 2009 ident: pone.0289047.ref032 publication-title: Statistical power analyses using G* Power 3.1: Tests for correlation and regression analyses – volume: 42 start-page: 127 issue: 2 year: 2010 ident: pone.0289047.ref021 article-title: A translational bridge between mouse and human models of learned safety publication-title: Annals of medicine doi: 10.3109/07853890903583666 – volume: 84 start-page: 65 issue: 1 year: 2000 ident: pone.0289047.ref003 article-title: Fear and anxiety: divergent effects on human pain thresholds publication-title: Pain doi: 10.1016/S0304-3959(99)00183-9 – volume: 42 start-page: 139 year: 1996 ident: pone.0289047.ref057 article-title: Untersuchungen mit einer deutschen Version der" Positive and Negative Affect Schedule"(PANAS) publication-title: Diagnostica-Gottingen – volume: 19 start-page: 216 issue: 2 year: 2015 ident: pone.0289047.ref033 article-title: Modulation of the startle reflex by heat pain: Does threat play a role? publication-title: European Journal of Pain doi: 10.1002/ejp.539 – volume: 59 start-page: 215 issue: 06 year: 2009 ident: pone.0289047.ref069 article-title: Evaluation der deutschsprachigen Version des Bindungsfragebogens “Experiences in Close Relationships–Revised”(ECR-RD) publication-title: Psychotherapie· Psychosomatik· Medizinische Psychologie doi: 10.1055/s-2008-1067425 – volume-title: Manual for the State-Trait Anxiety Inventory year: 1983 ident: pone.0289047.ref056 – volume: 12 start-page: 651 issue: 4 year: 2017 ident: pone.0289047.ref005 article-title: Orbitofrontal cortex mediates pain inhibition by monetary reward publication-title: Social Cognitive and Affective Neuroscience doi: 10.1093/scan/nsw173 – volume: 25 start-page: 49 issue: 1 year: 1994 ident: pone.0289047.ref040 article-title: Measuring emotion: the self-assessment manikin and the semantic differential publication-title: Journal of behavior therapy and experimental psychiatry doi: 10.1016/0005-7916(94)90063-9 – volume: 16 start-page: 26 issue: 1 year: 2008 ident: pone.0289047.ref063 article-title: Die deutsche Version des Life-Orientation-Tests (LOT-R) zum dispositionellen Optimismus und Pessimismus publication-title: Zeitschrift für Gesundheitspsychologie doi: 10.1026/0943-8149.16.1.26 – volume: 46 start-page: 939 issue: 5 year: 2009 ident: pone.0289047.ref029 article-title: Psychophysiological responses to pain: further validation of the nociceptive flexion reflex (NFR) as a measure of nociception using multilevel modeling publication-title: Psychophysiology doi: 10.1111/j.1469-8986.2009.00835.x – volume: 152 start-page: 592 issue: 3 year: 2011 ident: pone.0289047.ref039 article-title: Autonomic responses to heat pain: Heart rate, skin conductance, and their relation to verbal ratings and stimulus intensity publication-title: PAIN doi: 10.1016/j.pain.2010.11.032 – volume: 120 start-page: 995 issue: 5 year: 2006 ident: pone.0289047.ref041 article-title: Contingency awareness and fear inhibition in a human fear-potentiated startle paradigm publication-title: Behavioral Neuroscience doi: 10.1037/0735-7044.120.5.995 |
| SSID | ssj0053866 |
| Score | 2.4384515 |
| Snippet | The experience of threat was found to result—mostly—in increased pain, however it is still unclear whether the exact opposite, namely the feeling of safety may... The experience of threat was found to result-mostly-in increased pain, however it is still unclear whether the exact opposite, namely the feeling of safety may... |
| SourceID | plos doaj pubmedcentral proquest gale crossref |
| SourceType | Open Website Open Access Repository Aggregation Database Enrichment Source Index Database |
| StartPage | e0289047 |
| SubjectTerms | Affect (Psychology) Arousal Biology and Life Sciences Care and treatment Conditioning Contingency Cues Emotion regulation Evaluation Experiments Extinction Extinction behavior Heart rate Heat Learning Medicine and Health Sciences Pain Pain perception Perceptions Questionnaires Ratings Ratings & rankings Safety Social Sciences Temperature Visual stimuli |
| SummonAdditionalLinks | – databaseName: DOAJ Directory of Open Access Journals dbid: DOA link: http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwrV3NbtQwELbQnrggyo8aKGAQEnBIm7UdOz6hFlEVJFgJKOrNsh27rFQlq83uoTcegifkSRg7TrSRkMqByx7iSbT5ZsYzE88PQi-5Bx9fWp5XjomcGW1yqSuTE0Oss15arcOJ7qfP_OycfbwoL3ZGfYWcsL49cA_cEfO8MrTkQjvHSmu01MITO3cQZ3BpYx052LwhmOr3YNBizlOhHBXzo8SXw1XbuMN4thbGqewYotivf9yVZ6urtpu4nNOEyR0LdHoX3UmuIz7u__IeuuWae2gvKWeHX6cO0m_uo8VJLNLBnfYOh2_juGvX6-u3v3_-WjRwweHlMJsEtx7HyRGujuSba9w2eKWX8DPmvDxA56fvv707y9PkhNxyUWxyoQvPa0C_rIvaaIiSnLDzihdWMzDItKbaUFNSL1xVlIZJA14Vo577opZGCPoQzRrAah9hTrWklri6sBT0XZuSaMKc9NxxZqjLEB1gVDa1FQ_TLa5UPCsTEF708KgAvkrgZygf71r1bTVuoD8JHBppQ1PseAFERSVRUTeJSoaeBf6qvsJ0VG11LAS4RZwXVYZeRIrQGKMJmTeXett16sPi-z8Qff0yIXqViHwLcFidqh3gnULDrQnlwYQS1NtOlveDNA6odApiPEmAa6yEOwcJ_fvy83E5PDRk0zWu3XaKgGVhQhSSZKiaSPYE4OlKs_wRu4_PC05g12aP_gdLHqPbBLzGWNwpDtBss966J-DlbczTqNB_ABTHU1E priority: 102 providerName: Directory of Open Access Journals – databaseName: Health & Medical Collection dbid: 7X7 link: http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwjV3NbtQwELZguXBBlB91oYBBSMAhbdZ27PhUtYiqIMFKQNHeLNuxy0pVEja7h954CJ6QJ2HsdUIjIeCSQ_wlUWY89md7fhB6zj1wfGl5VjomMma0yaQuTUYMsc56abUOJ7rvP_DTM_ZuUSzShluX3Cr7MTEO1FVjwx75AVBbSUogGMVh-y0LVaPC6WoqoXEd3Qipy4JLl1gMCy6wZc5TuBwVs4Oknf22qd1-PGELRVWuTEcxa_8wNk_ai6YbEc-x2-SVeejkNrqVCCQ-2mp8B11z9R20k0y0wy9THulXd9H8OIbq4E57h8MOOe6a1ery8Of3H_Mabji87CuU4MbjWD_CVRG-vsRNjVu9hMvg-XIPnZ28-fz6NEv1EzLLRb7OhM49r0AHRZVXRsNayQk7K3luNYNpmVZUG2oK6oUDwRomDXArRj33eSWNEPQ-mtQgq12EOdWSWuKq3FKwem0Koglz0nPHmaFuimgvRmVTcvFQ4-JCxRMzAYuMrXhUEL5Kwp-ibHiq3SbX-Af-OGhowIbU2PFGszpXydIU87w0tOBCO8cKa7TUwhM7c7Aw5dLCS54E_aptnOlg4OpICCBHnOflFD2LiJAeow7-N-d603Xq7fzLf4A-fRyBXiSQb0AcVqeYB_inkHZrhNwbIcHI7ah5N_TGXiqd-m0O8GTfQ__c_HRoDi8NPnW1azadIjC_MCFySaaoHPXskYDHLfXya8xBPss5gbGbPfj71x-imwRYYQzeFHtosl5t3CNgcWvzOJrqL428SjY priority: 102 providerName: ProQuest |
| Title | Better safe than sorry?—On the influence of learned safety on pain perception |
| URI | https://www.proquest.com/docview/3069280545 https://www.proquest.com/docview/2887477092 https://pubmed.ncbi.nlm.nih.gov/PMC10629634 https://doaj.org/article/4f68b3567aee45cba9a7f2c1e91769c7 http://dx.doi.org/10.1371/journal.pone.0289047 |
| Volume | 18 |
| hasFullText | 1 |
| inHoldings | 1 |
| isFullTextHit | |
| isPrint | |
| link | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwjV3da9swEBdt-rKXse6Dpmszbwy2PTg4kizZD6M0JVk3SDu6ZeRNSLLUBYKdxQk0L_vbd1JsM0PH-iKw9ZPAJ53uzqe7Q-gts6Djp5qFiaE8pEqqMJWJCrHC2mibaimdR3dyxS6n9Mssnu2humZrRcDyXtPO1ZOarhb9u1_bM2D4j75qAx_Ug_rLIjd97zmjfB8dgGzijlUntPErAHd776XTWkKGI1IF0_1rlpaw8jn9m5O7s1wUZUstbV-q_EtKjZ-gx5V6GZzv9sMh2jP5U3RYMXAZvK-yTH94hiZDH8gTlNKawP0_D8pitdqehdc5PJpgXlcvCQob-NoSJvPg9TYo8mAp59A0t2Keo-l49P3iMqxqK4Sa8WgdchlZlsH6xFmUKQl2lOF6kLBISwoim2REKqJiYrlJoljRVIHeRYllNspSxTl5gTo5UOoIBYzIlGhsskgTOBGkirHE1KSWGUYVMV1EaiIKXSUed_UvFsJ70zgYIDviCEd6UZG-i8Jm1HKXeOM_-KFbnwbr0mb7F8XqVlRcKKhliSIx49IYGmslU8kt1gMDRitLNUzyyq2u2MWgNswvzjkHxYmxKOmiNx7hUmfk7m7OrdyUpfh8_eMBoG83LdC7CmQLIIeWVTwEfJNLydVCnrSQcADoVveR24s1VUoBVmCKYdVoDCPr_Xl_9-um203q7tvlptiUAoPsoZxHKe6ipLWvWwRu9-Tznz4_-SBiGM51evyA6V-iRxjURh_dyU9QZ73amFNQ89aqh_b5jEObXAxcO_7UQwfD0dXXm57_cdLznO3a36M_pUBYhw |
| linkProvider | Scholars Portal |
| linkToHtml | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwtR3LbtQw0CrLAS6I8lAXCjUIBBzSprZjJwdUtUDVpY-VoK16M7Zjl5WqZNnsCu2Nj-A7-Ci-hLE3CY2EgEsvOdgTJxnPM54HQs-4Axs_MzxKLRMR00pHmUp1RDQx1rjMKOVPdA-P-N4Je3-WnC2hH00ujA-rbGRiENR5afw_8g0wbTOSgoGRbI2_RL5rlD9dbVpoLMhi386_gstWvR68hf19Tsjuu-M3e1HdVSAyXMTTSKjY8RzeLMnjXCvwIKwwmymPjWKgrGhOlaY6oU5YeJxmmQaLg1HHXZxnWggK615D10Hxxp6jxFnr4IHs4LxOz6Nic6OmhvVxWdj1cKLnm7hcUn-hS0CrC3rji7LqGLrdMM1Lem_3NrpVG6x4e0Fhy2jJFnfQci0SKvyyrlv96i4a7oTUIFwpZ7H_I4-rcjKZb_389n1YwIDFo6YjCi4dDv0qbB7Ap3NcFnisRnBpI23uoZMrwex91CsAVysIc6oyaojNY0NByiidEEWYzRy3nGlq-4g2aJSmLmbue2pcyHBCJ8CpWaBHeuTLGvl9FLV3jRfFPP4Bv-N3qIX1pbjDQDk5lzVnS-Z4qmnChbKWJUarTAlHzKYFR5hnBhZZ8_srF3mtrUCR20KAMcZ5nPbR0wDhy3EUPt7nXM2qSg6Gp_8B9PFDB-hFDeRKQIdRdY4FfJMv89WBXO1AglAxnekVT40NVir5m_3gzoZC_zz9pJ32i_oYvsKWs0oS0GdMiDgjfZR2KLuD4O5MMfocap4DsxHQFezB35--hm7sHR8eyIPB0f5DdJOARRoSR8Uq6k0nM_sILMipfhzYFqNPVy0nfgG4DIbH |
| linkToPdf | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwtV3NbtQwELbKIiEuiPKjLhRqEAg4pM3ajp0cUNVSVi2FLgKKejO2Y5eVqmTZ7ArtjYfgaXgcnoRx1gmNhIBLL3uIJ052PJ75Jp4fhB5xBxg_MzxKLRMR00pHmUp1RDQx1rjMKOVPdN8c8f1j9uokOVlBP5pcGB9W2ejEWlHnpfHfyLcA2mYkBYCRbLkQFvF2b7g9-RL5DlL-pLVpp7EUkUO7-AruW_X8YA_W-jEhw5cfXuxHocNAZLiIZ5FQseM5vGWSx7lW4E1YYQYpj41iYLhoTpWmOqFOWHi0ZpkG9MGo4y7OMy0EhXkvocuCJgO_x8RJ6-yBHuE8pOpRMdgKkrE5KQu7WZ_u-YYu50xh3TGgtQu9yVlZdUBvN2TznA0cXkfXAnjFO0tpW0UrtriBVoN6qPDTUMP62U002q3ThHClnMX-6zyuyul0sf3z2_dRARcsHjfdUXDpcN27wuY1-WyBywJP1Bh-2qibW-j4Qjh7G_UK4NUawpyqjBpi89hQ0DhKJ0QRZjPHLWea2j6iDRulCYXNfX-NM1mf1glwcJbskZ75MjC_j6L2rsmysMc_6Hf9CrW0vix3faGcnsqwyyVzPNU04UJZyxKjVaaEI2ZgwSnmmYFJNvz6ymWOa6tc5I4QAMw4j9M-elhT-NIchRfyUzWvKnkw-vgfRO_fdYieBCJXAjuMCvkW8J98ya8O5XqHEhSM6QyveWlsuFLJ31sR7mwk9M_DD9phP6mP5ytsOa8kAdvGhIgz0kdpR7I7DO6OFOPPdf3zQcwJ2A125-9P30BXQEPI1wdHh3fRVQLgtM4hFeuoN5vO7T0AkzN9v961GH26aDXxC-i5iv0 |
| openUrl | ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Better+safe+than+sorry%3F-On+the+influence+of+learned+safety+on+pain+perception&rft.jtitle=PloS+one&rft.au=Zillig%2C+Anna-Lena&rft.au=Pauli%2C+Paul&rft.au=Wieser%2C+Matthias&rft.au=Reicherts%2C+Philipp&rft.date=2023-11-07&rft.issn=1932-6203&rft.eissn=1932-6203&rft.volume=18&rft.issue=11&rft.spage=e0289047&rft_id=info:doi/10.1371%2Fjournal.pone.0289047&rft.externalDBID=NO_FULL_TEXT |
| thumbnail_l | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=1932-6203&client=summon |
| thumbnail_m | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=1932-6203&client=summon |
| thumbnail_s | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=1932-6203&client=summon |