Elastin as a biomaterial for tissue engineering

Abstract Biomaterials based upon elastin and elastin-derived molecules are increasingly investigated for their application in tissue engineering. This interest is fuelled by the remarkable properties of this structural protein, such as elasticity, self-assembly, long-term stability, and biological a...

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Bibliographic Details
Published inBiomaterials Vol. 28; no. 30; pp. 4378 - 4398
Main Authors Daamen, W.F, Veerkamp, J.H, van Hest, J.C.M, van Kuppevelt, T.H
Format Journal Article
LanguageEnglish
Published Netherlands Elsevier Ltd 01.10.2007
Subjects
Advanced Basic Science
Animals
Biocompatible Materials - chemistry
Biomaterial
Dentistry
Elastic fibre
Elastin
Elastin - chemistry
Elastin - physiology
Elastin - ultrastructure
Humans
Models, Biological
Molecular Structure
Protein Structure, Tertiary
Review
Tissue Engineering - methods
Biomaterial
Review
Elastin
Elastic fibre
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Summary:Abstract Biomaterials based upon elastin and elastin-derived molecules are increasingly investigated for their application in tissue engineering. This interest is fuelled by the remarkable properties of this structural protein, such as elasticity, self-assembly, long-term stability, and biological activity. Elastin can be applied in biomaterials in various forms, including insoluble elastin fibres, hydrolysed soluble elastin, recombinant tropoelastin (fragments), repeats of synthetic peptide sequences and as block copolymers of elastin, possibly in combination with other (bio)polymers. In this review, the properties of various elastin-based materials will be discussed, and their current and future applications evaluated.
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ISSN:0142-9612
1878-5905
DOI:10.1016/j.biomaterials.2007.06.025