A tale of two specificities: bispecific antibodies for therapeutic and diagnostic applications

• Published in: Trends in biotechnology (Regular ed.) Vol. 31; no. 11; pp. 621 - 632
• Main Authors: Byrne, Hannah, Conroy, Paul J, Whisstock, James C, O’Kennedy, Richard J
• Format: Journal Article
• Language: English
• Published: Cambridge, MA Elsevier Ltd 01.11.2013; Cell Press; Elsevier Limited
• Subjects: antibodies; Antibodies, Bispecific - genetics; Antibodies, Bispecific - isolation & purification; Antibodies, Bispecific - therapeutic use; Antibodies, Monoclonal - genetics; Antibodies, Monoclonal - isolation & purification; Antibodies, Monoclonal - therapeutic use; Apoptosis; Binding sites; Biological and medical sciences; Biotechnology; Biotechnology - methods; Biotechnology - trends; Cytotoxicity; Deoxyribonucleic acid; DNA; Fundamental and applied biological sciences. Psychology; genes; Immune system; Internal Medicine; Melanoma; Molecular weight; Point-of-Care Systems - trends; Protein Engineering - methods; Protein Engineering - trends; Proteins; recombinant antibodies; Recombinant Proteins - genetics; Recombinant Proteins - isolation & purification; Recombinant Proteins - therapeutic use; Regulatory approval; Review; Single-Chain Antibodies - genetics; Single-Chain Antibodies - isolation & purification; Single-Chain Antibodies - therapeutic use; T cell receptors; Technological change; Technology, Pharmaceutical - methods; Technology, Pharmaceutical - trends; therapeutics; Drug; Specificity; Diagnosis; Bispecific antibody; Application
• ISSN: 0167-7799; 1879-3096
• DOI: 10.1016/j.tibtech.2013.08.007

Highlights • Recombinant DNA technologies are leading the rapid expansion of bispecific antibody formats. • The therapeutic potential of bispecific antibodies is being realized through creative design. • Bispecific antibodies are potentially underutilized reagents for diagnostics.