Endoplasmic reticulum stress and atherosclerosis

• Published in: Nature medicine Vol. 16; no. 4; pp. 396 - 399
• Main Author: Hotamisligil, Gökhan S
• Format: Journal Article
• Language: English
• Published: New York Nature Publishing Group US 01.04.2010; Nature Publishing Group
• Subjects: 631/80/470/1463; 631/80/86/2366; 692/698/690/292; 692/699/75/593/2100; Animals; Apoptosis - physiology; Atherosclerosis; Atherosclerosis - etiology; Biomedical and Life Sciences; Biomedicine; Cancer Research; Cardiovascular disease; Cardiovascular diseases; Chronic illnesses; commentary; Complications and side effects; Endoplasmic reticulum; Endoplasmic Reticulum - physiology; Health aspects; Humans; Immune response; Infectious Diseases; Inflammation - physiopathology; Lipid Metabolism - physiology; Macrophages - physiology; Metabolic Diseases; Metabolism; Molecular Medicine; Neurosciences; Nutrients; Obesity; Physiological aspects; Prevention; Stress; Stress (Physiology); Stress, Physiological - physiology; Unfolded Protein Response - physiology; United States
• ISSN: 1078-8956; 1546-170X
• DOI: 10.1038/nm0410-396

Atherosclerosis and related cardiovascular diseases represent one of the greatest threats to human health worldwide. Despite important progress in prevention and treatment, these conditions still account for one third of all deaths annually. Often presented together with obesity, insulin resistance and type 2 diabetes, these chronic diseases are strongly influenced by pathways that lie at the interface of chronic inflammation and nutrient metabolism. Here I discuss recent advances in the study of endoplasmic reticulum stress as one mechanism that links immune response with nutrient sensing in the pathogenesis of atherosclerosis and its complications.