Seroprevalence of neutralizing antibodies against human adenovirus type 55 in the South Korean military, 2018-2019

We conducted a seroprevalence study of a large ongoing outbreak of human adenovirus type 55 (HAdV-55) among the military in South Korea. Serum samples were collected between 2018 and 2019 from military-exposed (military group) and non-exposed (non-military group) populations. The plaque reduction ne...

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Published inPloS one Vol. 15; no. 7; p. e0236040
Main Authors Park, So Yun, Ko, Jae-Hoon, Monoldorova, Sezim, Jeong, Jonguk, Jeon, Bo-Young, Kwon, Soon-Hwan
Format Journal Article
LanguageEnglish
Published San Francisco Public Library of Science 16.07.2020
Public Library of Science (PLoS)
Subjects
Adenoviruses
Antibodies
Armed forces
Biology and life sciences
Chi-square test
Epidemics
Exposure
Human adenoviruses
Infectious diseases
Laboratories
Medical research
Medicine and Health Sciences
Military
Military personnel
Military service
Neutralization
Neutralizing
People and Places
Physical Sciences
Pneumonia
Population
Research and Analysis Methods
Serology
Social Sciences
Soldiers
Testing
South Korea
United States > US
China
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Summary:We conducted a seroprevalence study of a large ongoing outbreak of human adenovirus type 55 (HAdV-55) among the military in South Korea. Serum samples were collected between 2018 and 2019 from military-exposed (military group) and non-exposed (non-military group) populations. The plaque reduction neutralization test (PRNT) was used to assess neutralization activity against HAdV-55. A total of 100 sera was collected from the non-military group, of which 18.8% showed HAdV-55 neutralizing antibody activity. Ninety-six sera were tested from the military group, which had significantly higher prevalence of neutralizing antibodies (56.0%, P <0.001). A significantly higher proportion of the military group had PRNT titers [greater than or equal to]1:1,000 than the non-military group (85.7% vs. 50.0%, P = 0.004). Among the military group, 48.9% of active-duty soldiers had PRNT titers [greater than or equal to]1:5,000, while none of the discharged civilians did (P = 0.007). In conclusion, Koreans were exposed to HAdV-55 in their communities, but the exposure risk was higher among people in military service.
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Competing Interests: The authors have declared that no competing interests exist.
ISSN:1932-6203
1932-6203
DOI:10.1371/journal.pone.0236040