Impact of COVID-19 on quality checks of solid tumor molecular diagnostic testing-A surveillance by EQAS provider in India

• Published in: PloS one Vol. 17; no. 9; p. e0274089
• Main Authors: Shetty, Omshree, Shet, Tanuja, Iyer, Ramya, Gogte, Prachi, Gurav, Mamta, Joshi, Pradnya, Karnik, Nupur, Pai, Trupti, Epari, Sridhar, Desai, Sangeeta
• Format: Journal Article
• Language: English
• Published: San Francisco Public Library of Science 22.09.2022; Public Library of Science (PLoS)
• Subjects: Analysis; Cancer; Care and treatment; Control; Coronaviruses; COVID-19; COVID-19 diagnostic tests; Diagnosis; Diagnostic tests; Digital imaging; Disease transmission; Epidemics; Evaluation; Human resource management; India; Laboratories; Medical care; Medical diagnosis; Medicine and Health Sciences; Molecular diagnostic techniques; Oncology; Pandemics; Participation; Polls & surveys; Quality assessment; Quality assurance; Quality control; Quality management; Reagents; Research and Analysis Methods; Safety measures; Severe acute respiratory syndrome coronavirus 2; Skills; Solid tumors; Surveys; Test procedures; Testing laboratories; Testing procedures; Tumors; India
• ISSN: 1932-6203; 1932-6203
• DOI: 10.1371/journal.pone.0274089

Background Molecular tests in solid tumours for targeted therapies call for the need to ensure precision testing. To accomplish this participation in the External Quality Assessment Program (EQAS) is required. This evaluates the consistency of diagnostic testing procedures and offers guidance for improving quality. Outbreak of COVID-19 pandemic led to worldwide lockdown and disruption of healthcare services including participation in EQAS.The present study describes the extended scope of EQAS offered byMPQAP (Molecular Pathology Quality Assurance Program), the first proficiency test provider for solid tumor diagnostics in India. The study surveys the preparedness of molecular testing laboratories in routine diagnostics and participation for quality assessment scheme. Methods A documented guideline for measures and precautions to be carried by testing laboratories in performing routine diagnostic tests during the lockdown period were charted and distributed to all MPQAP participant centres. A survey was conducted for MPQAP participants to check whether laboratories were involved in COVID-19 testing and to evaluate the impact of lockdown on the operations of diagnostics procedures. From the acquired response of the survey, 2 cycles out of initially proposed 11 cycles were executed with transformed approach using digital tools and image interpretation modules. Findings Out of 25 solid tumour testing laboratories registered as participants, 15 consented to participate in survey. The summary of survey conveyed the impact of COVID-19onroutine operations of diagnostics tests such as shortcomings in inventory and human resource management. Thirteen participants showed active willingness and consented to participate in EQAS test scheme. Interpretations The survey findings and assessment of EQAS cycles endorsed the quality testing procedures carried by participating laboratories throughout the lockdown. It highlighted the utility of EQAS participation during pandemic along with emphasis on safety measures for continual improvement in quality of diagnostic services.