A pan-cancer bioinformatic analysis of the carcinogenic role of SMARCA1 in human carcinomas

• Published in: PloS one Vol. 17; no. 9; p. e0274823
• Main Authors: Dai, Lei, Mugaanyi, Joseph, Zhang, Tongyue, Tong, Jingshu, Cai, Xingchen, Lu, Caide, Lu, Changjiang
• Format: Journal Article
• Language: English
• Published: San Francisco Public Library of Science 20.09.2022; Public Library of Science (PLoS)
• Subjects: Adenocarcinoma; Analysis; Breast cancer; Cancer; Carcinogens; CD8 antigen; Chromatin remodeling; Colon; Colorectal cancer; Consortia; Diagnosis; Endometrial cancer; Endometrium; Fibroblasts; Gastric cancer; Gene expression; Genetic aspects; Genomes; Genomics; Genotype & phenotype; Genotypes; Head and neck carcinoma; Infiltration; Kidney cancer; Liver cancer; Lung cancer; Lung carcinoma; Lungs; Lymphocytes T; Medical prognosis; Medicine and Health Sciences; Metastases; Ovarian cancer; Phosphorylation; Proteins; Sarcoma; Squamous cell carcinoma; Tumors; Uterine cancer; Uterus; China; United States > US; California
• ISSN: 1932-6203; 1932-6203
• DOI: 10.1371/journal.pone.0274823

SMARCA1is a mammalian imitation switch (ISWI) gene that encodes for SNF2L. SNF2L is involved in regulating cell transition from a committed progenitor state to a differentiated state. Although many papers have detailed the correlation between SMARCA1 and different cancers, no pan-cancer analysis has been conducted to date. We started by exploring the potential carcinogenic role of SMARCA1 across 33 carcinomas using the cancer genome atlas (TCGA) and the genotype-tissue expression (GTEx) databases. The expression of SMARCA1 was significantly elevated in some tumor types but not in others. There was a distinct relationship between SMARCA1 expression and patient prognosis. S116 phosphorylation levels were up-regulated in both lung adenocarcinoma and uterine corpus endometrial carcinoma. The expression level of SMARCA1 was positively correlated with cancer-associated fibroblasts infiltration in a number of tumors, such as colon adenocarcinoma, cervical squamous cell carcinoma and endocervical adenocarcinoma. It was also associated with CD8+ T-cell infiltration in head and neck squamous cell carcinoma and lung adenocarcinoma. Furthermore, SMARCA1 is involved in chromatin remodeling and protein processing-associated mechanisms. Our study presents an initial assessment and illustration of the carcinogenic role of SMARCA1 in different carcinomas.