Alzheimer's Disease Is a Synaptic Failure

In its earliest clinical phase, Alzheimer's disease characteristically produces a remarkably pure impairment of memory. Mounting evidence suggests that this syndrome begins with subtle alterations of hippocampal synaptic efficacy prior to frank neuronal degeneration, and that the synaptic dysfu...

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Bibliographic Details
Published inScience (American Association for the Advancement of Science) Vol. 298; no. 5594; pp. 789 - 791
Main Author Selkoe, Dennis J.
Format Journal Article
LanguageEnglish
Published United States American Association for the Advancement of Science 25.10.2002
The American Association for the Advancement of Science
Subjects
Alzheimer Disease - pathology
Alzheimer Disease - physiopathology
Alzheimer's disease
Alzheimers Disease
Amyloid beta-Peptides - genetics
Amyloid beta-Peptides - metabolism
Amyloid beta-Protein Precursor - genetics
Amyloid beta-Protein Precursor - metabolism
Animals
Brain
Brain - pathology
Brain - physiopathology
Cognition
Evidence
Humans
Long term potentiation
Membrane Proteins - genetics
Memory
Mice
Mice, Transgenic
Molecular neurobiology
Nervous system diseases
Neurology
Neurons
Neuroscience
Numbers
Oligomers
Patients
Presenilin-1
Proteins
Synapses
Synapses - physiology
Synapses - ultrastructure
Synaptic Transmission
Transgenic animals
Viewpoints
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Summary:In its earliest clinical phase, Alzheimer's disease characteristically produces a remarkably pure impairment of memory. Mounting evidence suggests that this syndrome begins with subtle alterations of hippocampal synaptic efficacy prior to frank neuronal degeneration, and that the synaptic dysfunction is caused by diffusible oligomeric assemblies of the amyloid β protein.
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ISSN:0036-8075
1095-9203
DOI:10.1126/science.1074069