Why sickness hurts: A central mechanism for pain induced by peripheral inflammation

• Published in: Brain, behavior, and immunity Vol. 57; pp. 38 - 46
• Main Authors: Karshikoff, B, Jensen, K.B, Kosek, E, Kalpouzos, G, Soop, A, Ingvar, M, Olgart Höglund, C, Lekander, M, Axelsson, J
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier Inc 01.10.2016
• Subjects: Adolescent; Adult; Allergy and Immunology; Anterior cingulate cortex; Chronic pain; Cytokines; Cytokines - blood; Descending pain inhibition; Female; fMRI; Gyrus Cinguli - diagnostic imaging; Gyrus Cinguli - physiopathology; Humans; Inflammation - blood; Inflammation - chemically induced; Insula; Interoception - physiology; Lipopolysaccharide; Lipopolysaccharides - administration & dosage; Lipopolysaccharides - pharmacology; Magnetic Resonance Imaging; Male; Medicin och hälsovetenskap; Middle Aged; Pain - diagnostic imaging; Pain - etiology; Pain - physiopathology; Pain Perception - physiology; Pre-frontal cortex; Prefrontal Cortex - diagnostic imaging; Prefrontal Cortex - physiopathology; Psychiatry; Random Allocation; Sex Factors; Sickness behavior; Young Adult; Lipopolysaccharide; Insula; Sickness behavior; Cytokines; Anterior cingulate cortex; Chronic pain; fMRI; Pre-frontal cortex; Descending pain inhibition
• ISSN: 0889-1591; 1090-2139; 1090-2139
• DOI: 10.1016/j.bbi.2016.04.001

Highlights • Experimental. • inflammation down-regulates the descending inhibitory pain pathway. • Inflammation induces stronger affective and interoceptive pain related brain activity. • Women had an overall weaker descending pain inhibition, rendering them more sensitive to the inflammatory provocation.