Sex differences in impulsive action and impulsive choice

• Published in: Addictive behaviors Vol. 39; no. 11; pp. 1573 - 1579
• Main Authors: Weafer, Jessica, de Wit, Harriet
• Format: Journal Article
• Language: English
• Published: England Elsevier Ltd 01.11.2014; Elsevier Science Ltd
• Subjects: Addictive behaviors; Animals; Animals, Laboratory; Choice Behavior - physiology; Female; Gender differences; Gonadal Steroid Hormones - physiology; Hormones; Humans; Impulsive action; Impulsive Behavior - physiology; Impulsive choice; Impulsivity; Laboratory animals; Male; Mice; Neuroimaging; Psychiatry; Rats; Sex differences; Sex Factors; Substance-Related Disorders - psychology; Sex differences; Impulsive action; Impulsive choice; Laboratory animals; Humans
• ISSN: 0306-4603; 1873-6327; 1873-6327
• DOI: 10.1016/j.addbeh.2013.10.033

Here, we review the evidence for sex differences in behavioral measures of impulsivity for both humans and laboratory animals. We focus on two specific components of impulsivity: impulsive action (i.e., difficulty inhibiting a prepotent response) and impulsive choice (i.e., difficulty delaying gratification). Sex differences appear to exist on these measures, but the direction and magnitude of the differences vary. In laboratory animals, impulsive action is typically greater in males than females, whereas impulsive choice is typically greater in females. In humans, women discount more steeply than men, but sex differences on measures of impulsive action depend on tasks and subject samples. We discuss implications of these findings as they relate to drug addiction. We also point out the major gaps in this research to date, including the lack of studies designed specifically to examine sex differences in behavioral impulsivity, and the lack of consideration of menstrual or estrous phase or sex hormone levels in the studies. •In laboratory animals and humans, females tend to discount more steeply than males.•In laboratory animals, males tend to show greater impulsive action than females.•In humans, sex differences in impulsive action depend on tasks and subject samples.•Among heavy drinkers and smokers, women show greater impulsive action than men.