High-Dose Chemotherapy for Breast Cancer
To the Editor: The conclusion drawn by Rodenhuis et al. (July 3 issue) 1 — that high-dose therapy improves relapse-free survival among patients with 10 or more positive nodes — is untenable. The authors failed to apply the method specified in their Statistical Analysis section — namely, the use of t...
Saved in:
Published in | The New England journal of medicine Vol. 349; no. 15; pp. 1476 - 1479 |
---|---|
Main Authors | , , |
Format | Journal Article |
Language | English |
Published |
United States
Massachusetts Medical Society
09.10.2003
|
Subjects | |
Online Access | Get full text |
Cover
Loading…
Summary: | To the Editor:
The conclusion drawn by Rodenhuis et al. (July 3 issue)
1
— that high-dose therapy improves relapse-free survival among patients with 10 or more positive nodes — is untenable. The authors failed to apply the method specified in their Statistical Analysis section — namely, the use of tests for interaction to evaluate differences in the treatment effect within subgroups. Such analysis does not provide good evidence that there is greater benefit for patients with 10 or more positive nodes than for those with fewer than 10. The P values in individual subgroups are unimportant; the P value for . . . |
---|---|
Bibliography: | SourceType-Other Sources-1 content type line 63 ObjectType-Correspondence-1 ObjectType-Commentary-2 |
ISSN: | 0028-4793 1533-4406 |
DOI: | 10.1056/NEJM200310093491515 |