A meta-analysis of cohort studies: Traumatic brain injury and risk of Alzheimer’s Disease

Recently, some epidemiological studies have reported that cognitive disorders in elderly people is accelerated with traumatic brain injury. But the causal relationship between traumatic brain injury and AD is still an area of controversy. Our review was conducted to estimate the relation between tra...

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Published inPloS one Vol. 16; no. 6; p. e0253206
Main Authors Zhang, Jieyu, Zhang, Yongkang, Zou, Juntao, Cao, Fei
Format Journal Article
LanguageEnglish
Published San Francisco Public Library of Science 22.06.2021
Public Library of Science (PLoS)
Subjects
Alzheimer's disease
Bias
Brain
Cohort analysis
Criteria
Dementia
Dementia disorders
Falls
Flow charts
Head injuries
Health risks
Hypertension
Injuries
Injury analysis
Medical ethics
Medicine and Health Sciences
Meta-analysis
Neurodegeneration
Neurodegenerative diseases
Patients
Physical Sciences
Research and Analysis Methods
Risk
Risk factors
Science Policy
Traumatic brain injury
China
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Summary:Recently, some epidemiological studies have reported that cognitive disorders in elderly people is accelerated with traumatic brain injury. But the causal relationship between traumatic brain injury and AD is still an area of controversy. Our review was conducted to estimate the relation between traumatic brain injury and risk of AD. All longitudinal population-based studies comparing incidence of AD between subjects with and without traumatic brain injury from their inception to September 2020 were searched in The Cochrane Library, PubMed, Medline, Embase, Web of Science without restriction of language. The meta-analysis was conducted using Stata software. A total of 17 studies involving 4289,548 individuals were included. After pooling these 17 studies, subjects with traumatic brain injury had significant higher incidence of AD than those without traumatic brain injury (RR: 1.17, 95% CI: 1.05-1.29). When considering the severity of traumatic brain injury, this elevated risk of AD was still significant comparing subjects with moderate and severe traumatic brain injury and those with no traumatic brain injury (RR: 1.30, 95% CI: 1.01-1.59). Traumatic brain injury, especially moderate and severe traumatic brain injury may be associated with increased risk of AD.
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Competing Interests: The authors have declared that no competing interests exist
ISSN:1932-6203
1932-6203
DOI:10.1371/journal.pone.0253206