Relationship between blood manganese and bone mineral density and bone mineral content in adults: A population-based cross-sectional study

• Published in: PloS one Vol. 17; no. 10; p. e0276551
• Main Authors: Wang, Chao, Zhu, Yong, Long, Haitao, Ou, Mingning, Zhao, Shushan
• Format: Journal Article
• Language: English
• Published: San Francisco Public Library of Science 21.10.2022; Public Library of Science (PLoS)
• Subjects: Age; Arthritis; Biology and Life Sciences; Blood; Body mass index; Bone density; Bone loss; Bone mineral content; Bone mineral density; Bones; Cardiovascular disease; Cross-sectional studies; Density; Diabetes; Ethnicity; Evaluation; Femur; Fractures; Hispanic people; Hypertension; Manganese; Medicine and Health Sciences; Mortality; Nutrition; Osteoarthritis; Osteopenia; Osteoporosis; People and places; Physical Sciences; Population; Population studies; Population-based studies; Regression analysis; Regression models; Risk factors; Smoking; Spine; Stroke; Subgroups; Thyroid gland; Variables; Womens health; China; United States > US
• ISSN: 1932-6203; 1932-6203
• DOI: 10.1371/journal.pone.0276551

It has been reported that bone is the primary organ for manganese (Mn) accumulation, but the association between manganese and bone loss remains debatable. Therefore, this study aimed to evaluate the relationship between blood manganese and bone mineral density/bone mineral content (BMD/BMC) by using a representative sample from the National Health and Nutrition Examination Survey (NHANES). A total of 9732 subjects over the age of 18 with available data were enrolled in this study. The relationship between blood manganese and BMD/BMC of the total body, spine and femoral regions was evaluated using multivariate linear regression models. Subgroup analyses were also performed. We observed a negative association between blood manganese and BMD/BMC in the femoral neck and total body in the fully adjusted model, especially femoral neck BMD in women aged 50-70 years. In brief, people exposed to manganese should be aware of the increased risk of osteopenia or osteoporosis. Besides, due to the lack of available data, there are no definite values for the tolerable upper intake level (UL), average requirement (AR) and population reference intake (PRI) of manganese. The results of our study may provide some references for the establishment of AR, PRI and UL of Mn.