Interferon gamma release assays for diagnosis of osteoarticular tuberculosis: A systematic review and meta-analysis

Although the Interferon Gamma Release Assays (IGRA) is often used to identify latent tuberculosis, it also plays a crucial role in diagnosing active extrapulmonary tuberculosis. Some studies have assessed the use of IGRA as a biomarker for osteoarticular tuberculosis (OATB), which is elevated follow...

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Published inPloS one Vol. 17; no. 6; p. e0269234
Main Authors Ren, Chunnian, Tang, Jie, Xia, Liangfeng
Format Journal Article
LanguageEnglish
Published San Francisco Public Library of Science 30.06.2022
Public Library of Science (PLoS)
Subjects
Accuracy
Analysis
Antigens
Bias
Biological response modifiers
Biology and Life Sciences
Biomarkers
Biomedical materials
Bivariate analysis
Diagnosis
Enzymes
Health aspects
Health risks
Infectious diseases
Interferon
Interferon gamma
Medical diagnosis
Medical ethics
Medicine and Health Sciences
Meta-analysis
Pathology
Physical Sciences
Research and Analysis Methods
Science Policy
Sensitivity
Systematic review
Tuberculosis
China
United Kingdom > UK
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Summary:Although the Interferon Gamma Release Assays (IGRA) is often used to identify latent tuberculosis, it also plays a crucial role in diagnosing active extrapulmonary tuberculosis. Some studies have assessed the use of IGRA as a biomarker for osteoarticular tuberculosis (OATB), which is elevated following TB infection. Still, conclusive results about its effectiveness have not been reported. We searched PubMed, Embase, and Cochran databases. We obtained literature related to the diagnosis of OATB by IGRA, and the retrieval period was from the establishment of the database to June 2021. The bivariate random effect model was used to summarize the sensitivity, specificity, and accuracy of other indicators in diagnosing OATB by IGRA, and the forest plot and receiver operating characteristic (ROC) curve were used for testing. We included seven studies involving 643 subjects in diagnosing OATB by IGRA. The comprehensive sensitivity and specificity were 0.84 (95% CI, 0.70-0.92) and 0.78 (95% CI, 0.66-0.87), respectively. The area under the curve (AUC) was 0.87. In blood samples, the diagnostic accuracy of IGRAS is poor in patients with suspected OAT. We conclude that IGRA may not be appropriate for patients with OATB.
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Competing Interests: The authors declare that they have no competing interests.
ISSN:1932-6203
1932-6203
DOI:10.1371/journal.pone.0269234