Glucose levels between the anterior chamber of the eye and blood are correlated based on blood glucose dynamics

• Published in: PloS one Vol. 16; no. 9; p. e0256986
• Main Authors: Kurihara, Toshihide, Lee, Deokho, Shinojima, Ari, Kinoshita, Taku, Nishizaki, Saori, Arita, Yoko, Hidaka, Yuki, Nishi, Yasuyo, Shirakawa, Yoshinori, Kimura, Sho, Tsuneyoshi, Yukari, Torii, Hidemasa, Tsubota, Kazuo, Negishi, Kazuno
• Format: Journal Article
• Language: English
• Published: San Francisco Public Library of Science 01.09.2021; Public Library of Science (PLoS)
• Subjects: Analysis; Anterior chamber; Anterior chamber (Eye); Biology and Life Sciences; Blood; Blood glucose; Blood sugar; Cardiac arrhythmia; Cataracts; Chambers; Complications; Correlation; Damage prevention; Diabetes; Diabetes mellitus; Diabetic neuropathy; Diabetic retinopathy; Disease; Eye surgery; Glucose; Glucose monitoring; Hexokinase; Hydrogen peroxide; Hypertension; Laboratories; Measurement; Medicine; Medicine and Health Sciences; Metabolic disorders; Methods; Monitoring; Photobiology; Physical Sciences; Japan
• ISSN: 1932-6203; 1932-6203
• DOI: 10.1371/journal.pone.0256986

Glycemic control is essential to manage metabolic diseases such as diabetes. Frequent measurements of systemic glucose levels with prompt managements can prevent organ damages. The eye is a glucose highly demanding organ in our body, and the anterior chamber (AC) in the eye has been suggested for a noninvasive blood glucose monitoring site. However, calculating blood glucose levels from measuring glucose levels in AC has been difficult and unclear. In this study, we aimed to examine glucose levels from AC and find a correlation with blood glucose levels. A total of 30 patients with cataracts (men and women, study 1; 7 and 3, study 2; 9 and 11) who visited Keio University Hospital from 2015 to 2018 and agreed to participate in this study were recruited. Glucose levels from AC and the blood were examined by a UV-hexokinase or H.sub.2 O.sub.2 -electrode method before/during the cataract surgery. These values were analyzed with regression analyses depending on the groups (blood glucose-ascending and descending groups). In the blood glucose-descending group, glucose levels from AC were strongly correlated with blood glucose levels (a high R.sup.2 value, 0.8636). However, the relatively moderate correlation was seen in the blood glucose-ascending group (a low R.sup.2 value, 0.5228). Taken together, we showed different correlation ratios on glucose levels between AC and the blood, based on blood glucose dynamics. Stacking data regarding this issue would enable establishing noninvasive blood glucose monitoring from measuring glucose levels in AC more correctly, which will be helpful for proper and prompt managements for glucose-mediated complications.