Evidence of innate lymphoid cell redundancy in humans

• Published in: Nature immunology Vol. 17; no. 11; pp. 1291 - 1299
• Main Authors: Vély, Frédéric, Barlogis, Vincent, Vallentin, Blandine, Neven, Bénédicte, Piperoglou, Christelle, Ebbo, Mikael, Perchet, Thibaut, Petit, Maxime, Yessaad, Nadia, Touzot, Fabien, Bruneau, Julie, Mahlaoui, Nizar, Zucchini, Nicolas, Farnarier, Catherine, Michel, Gérard, Moshous, Despina, Blanche, Stéphane, Dujardin, Arnaud, Spits, Hergen, Distler, Jörg H W, Ramming, Andreas, Picard, Capucine, Golub, Rachel, Fischer, Alain, Vivier, Eric
• Format: Journal Article
• Language: English
• Published: New York Nature Publishing Group US 01.11.2016; Nature Publishing Group
• Subjects: 13; 13/31; 631/250/2504; 692/699/249; Adolescent; Adult; Animals; B cells; Biomarkers; Biomedicine; Child; Disease Models, Animal; Genetic aspects; Graft Survival; Hematopoietic Stem Cell Transplantation; Humans; Immune system; Immune System - cytology; Immune System - immunology; Immune System - metabolism; Immunity, Innate; Immunology; Infectious Diseases; Interleukin Receptor Common gamma Subunit - deficiency; Intestinal Mucosa - immunology; Intestinal Mucosa - pathology; Janus Kinase 3 - deficiency; Life Sciences; Lymphocyte Count; Lymphocyte Subsets - immunology; Lymphocyte Subsets - metabolism; Lymphocytes - immunology; Lymphocytes - metabolism; Lymphopenia - blood; Lymphopenia - etiology; Medical research; Mice; Mice, Knockout; Phenotype; Severe Combined Immunodeficiency - blood; Severe Combined Immunodeficiency - immunology; Severe Combined Immunodeficiency - metabolism; Severe Combined Immunodeficiency - therapy; Skin - immunology; Skin - pathology; Stem cells; T cells
• ISSN: 1529-2908; 1529-2916
• DOI: 10.1038/ni.3553

The importance of human innate lymphoid cells to normal human physiology is unclear. Vivier and colleagues find that immunodeficient patients ‘rescued’ with normal bone marrow can recover their T cells but not their innate lymphoid cells, yet remain entirely asymptomatic for nearly 40 years. Innate lymphoid cells (ILCs) have potent immunological functions in experimental conditions in mice, but their contributions to immunity in natural conditions in humans have remained unclear. We investigated the presence of ILCs in a cohort of patients with severe combined immunodeficiency (SCID). All ILC subsets were absent in patients with SCID who had mutation of the gene encoding the common γ-chain cytokine receptor subunit IL-2Rγ or the gene encoding the tyrosine kinase JAK3. T cell reconstitution was observed in patients with SCID after hematopoietic stem cell transplantation (HSCT), but the patients still had considerably fewer ILCs in the absence of myeloablation than did healthy control subjects, with the exception of rare cases of reconstitution of the ILC1 subset of ILCs. Notably, the ILC deficiencies observed were not associated with any particular susceptibility to disease, with follow-up extending from 7 years to 39 years after HSCT. We thus report here selective ILC deficiency in humans and show that ILCs might be dispensable in natural conditions, if T cells are present and B cell function is preserved.